ArticleFrontiers in neurology2026
Pediatric stroke in inborn errors of metabolism: clinical characteristics, neuroimaging features, and short-term outcomes.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Pediatric stroke has a broad etiological spectrum, with inborn errors of metabolism (IEM) increasingly recognized as an important and potentially treatable cause. This study aimed to characterize the clinical, radiological, and electroencephalographic features of IEM-related pediatric stroke and to evaluate short-term functional outcomes. Methods: This prospective cohort study was conducted at The Children's Hospital Lahore, Pakistan, and Sultan Qaboos University Hospital, Muscat, Oman (January 2024-December 2025). Children with confirmed stroke secondary to IEM were enrolled. Functional outcome was assessed at 3 months using the modified Rankin Scale (mRS), with scores 0-3 defined as favorable and 4-6 as unfavorable. Results: Forty-four patients were included (59.1% male), with a mean age of 4.6 ± 4.2 years. Focal neurological deficits and encephalopathy were the most frequent presentations. Mitochondrial disorders and homocystinuria were the leading etiologies. MRI demonstrated heterogeneous patterns, most commonly focal ischemic lesions and brainstem-striatal involvement. Management included mitochondrial cocktails, vitamin therapy, and targeted metabolic treatments. Poorer outcomes (mRS 4-6) were associated with generalized epileptiform discharges with diffuse slowing on EEG, whereas favorable outcomes correlated with focal epileptiform discharges or normal EEG findings ( Conclusion: IEM represent an important and potentially treatable cause of pediatric stroke, particularly in populations with high consanguinity. Recognition of characteristic clinical features, distinctive MRI patterns, and supportive EEG findings can facilitate early diagnosis. Prompt metabolic and genetic evaluation is essential to guide targeted therapy and improve outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.