Volume-inflation registration (INFREG) for morphometric analysis of human focal cortical dysplasia type II.

Yongsheng Zhang, Haojie Han, Fang Chen, Hongen Liao

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yongsheng ZhangSchool of Biomedical Engineering, Tsinghua University, Beijing 100084, China.

Haojie HanSchool of Biomedical Engineering, Tsinghua University, Beijing 100084, China.

Fang ChenSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Hongen LiaoSchool of Biomedical Engineering, Tsinghua University, Beijing 100084, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodevelopmental expansion of human association cortex increases cortical folding complexity, causing registration inaccuracies that confound detection of subtle pathological signatures like focal cortical dysplasia (FCD) in voxel-based morphometry. We introduce INFREG (volume-inflation registration), integrating surface-based deformation with volumetric alignment to minimize sulcal smoothing. Validated on 80 histologically confirmed FCD cases and 85 controls, INFREG outperformed conventional methods (CAT12/Demons/BrainSuite) by (i) superior template to subject alignment (SSIM = 0.95 ± 0.04; GM/WM Dice = 0.93 ± 0.05 vs. 0.70-0.87, all

Indexed as

brainfocal cortical dysplasiainflationregistrationvoxel-based morphometry

Identifiers

PMID42755994

DOI10.1016/j.isci.2026.117446

PMCPMC13582014

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.