ArticleFrontiers in behavioral neuroscience2026
Reciprocal brain-behavior associations in gambling disorder revealed by theta cordance and directional predictive modeling.
Article in Frontiers in behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Gambling disorder (GD) is a behavioral addiction characterized by impaired impulse control and fronto-limbic cortical dysfunction. EEG theta cordance, which integrates absolute and relative power to index regional cerebral perfusion and metabolism, has not previously been combined with directional predictive modeling in behavioral addiction research. Objective: To compare regional resting-state theta cordance between GD patients and healthy controls (HCs), and to examine directional predictive associations between cortical cordance and clinical severity indices. Methods: In this retrospective observational study, 28 male patients with DSM-5 GD and 29 male HCs underwent 21-channel resting-state EEG (eyes-closed, 3-min artifact-free epochs; 4-8 Hz). Theta cordance was computed using the Leuchter algorithm and averaged into eight regions of interest. Clinical measures included the South Oaks Gambling Screen (SOGS), Beck Depression Inventory-II, Beck Anxiety Inventory, and illness duration. Group differences were tested with independent-samples Results: GD patients showed significantly lower central (0.03 ± 1.18 vs. 1.25 ± 1.23; Conclusion: Cortical theta cordance and clinical severity in GD appear reciprocally associated within an exploratory directional framework. Findings are preliminary given the modest, male-only, single-site sample and cross-sectional design, and require longitudinal confirmation.
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