Evidence map›Paper›PMID 42755940›Full record

ArticleiScience2026

Integrative proteomics defines FANCA as a multifunctional hub linking DNA repair to translation.

Virgile Gibert, Frédérique Maczkowiak-Chartois, Benedetta Mancini, Emilie-Fleur Gautier, Johanna Bruce, Morgane Le Gall, Serge Urbach, Angelos Constantinou, Anne Helbling-Leclerc, Jihane Basbous and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Virgile GibertUniversité Paris-Saclay, Gustave Roussy, CNRS, 94805 Villejuif, France.
Frédérique Maczkowiak-ChartoisUniversité Paris-Saclay, Gustave Roussy, CNRS, 94805 Villejuif, France.
Benedetta ManciniUniversité Paris-Saclay, Gustave Roussy, CNRS, 94805 Villejuif, France.
Emilie-Fleur GautierProteom'IC Facility, Université Paris Cité, CNRS, INSERM, Institut Cochin, 75014 Paris, France.
Johanna BruceProteom'IC Facility, Université Paris Cité, CNRS, INSERM, Institut Cochin, 75014 Paris, France.
Morgane Le GallProteom'IC Facility, Université Paris Cité, CNRS, INSERM, Institut Cochin, 75014 Paris, France.
Serge UrbachIGF, Université Montpellier, CNRS, 34094 Montpellier, France.
Angelos ConstantinouIGH, Université Montpellier, CNRS, 34094 Montpellier, France.
Anne Helbling-LeclercUniversité Paris-Saclay, Gustave Roussy, CNRS, 94805 Villejuif, France.
Jihane BasbousIGH, Université Montpellier, CNRS, 34094 Montpellier, France.
Filippo RosselliUniversité Paris-Saclay, Gustave Roussy, CNRS, 94805 Villejuif, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fanconi anemia (FA) is a genome instability syndrome caused by defects in the FANC/BRCA DNA repair pathway, yet its broad clinical heterogeneity suggests functions beyond DNA repair. Using an integrative interactomics strategy combining endogenous co-immunoprecipitation, proximity-dependent labeling,

Indexed as

DNA damage responseDNA repairfanconi anemiainteractomereplication stressribosomespliceosome

Identifiers

PMID42755940
PMCPMC13581985

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.