Evidence map›Paper›PMID 42755823›Full record

ArticleFrontiers in oncology2026

Prognostic value of a modified lymph node ratio for combined colorectal cancer tumour deposits: a population-based study.

Mingming Song, Feihong Wu, Yixin Heng, Tong Nie, Zhihao Liu, Jiaxin Xu, Xiaoyu Wu, Xiaoling Zhi, Wanrui Zhang, Zhixiang Yang and 3 more

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In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Mingming Song *Department of General Surgery, The Second People's Hospital of Hefei Affiliated to Bengbu Medical University, Hefei, China.
Feihong Wu *Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yixin HengDepartment of General Surgery, The First Affiliated Hospital of Shihezi University, Shihezi, China.
Tong NieDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhihao LiuChina Medical University, Shenyang, China.
Jiaxin XuDepartment of General Surgery, The First Affiliated Hospital of Shihezi University, Shihezi, China.
Xiaoyu WuDepartment of General Surgery, The First Affiliated Hospital of Shihezi University, Shihezi, China.
Xiaoling ZhiDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wanrui ZhangDepartment of General Surgery, The First Affiliated Hospital of Shihezi University, Shihezi, China.
Zhixiang YangDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Menghui DaiCancer center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jiaqi WangDepartment of Urology, Harbin Medical University Cancer Hospital, Harbin, China.
Gang HuDepartment of General Surgery, The Second People's Hospital of Hefei Affiliated to Bengbu Medical University, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tumour deposits (TDs) without metastatic lymph nodes are classified as N1c in the 8th edition of the AJCC staging manual. However, the prognostic value of TDs and lymph node ratio (LNR) in stage III colorectal cancer (CRC) remains unclear. This study aimed to compare the prognostic significance of TD count and LNR with the newly developed modified lymph node ratio (mLNR), and to create a prognostic nomogram integrating mLNR for stage III CRC patients. Methods: Using the SEER database, a training cohort of 25,689 stage III CRC patients was identified, alongside an external validation cohort of 563 patients from a hospital in China. Modified lymph node ratio (mLNR) was defined by combining TD count and LNR. The effects of TDs, LNR, and mLNR on cancer-specific survival (CSS) and overall survival (OS) were evaluated using Kaplan-Meier curves and Cox regression models. A nomogram incorporating mLNR was developed for prognosis prediction. Results: In both cohorts, TDs positivity was associated with poorer CSS (all P < 0.001). Multiple TDs correlated with worse CSS than a single TD (training: HR, 1.978; validation: HR, 1.805). High mLNR indicated a significantly higher risk of CRC-specific death (training: HR, 2.421; validation: HR, 4.60). The nomogram incorporating mLNR demonstrated good discrimination and calibration in both cohorts. Conclusions: mLNR is an independent prognostic factor for stage III CRC. The nomogram combining mLNR can effectively identify high-risk patients, aiding treatment decisions.

Indexed as

colorectal cancerlymph node rationomogramprognosistumor deposits

Identifiers

PMID42755823
PMCPMC13581868

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