ArticleFrontiers in medicine2026
Case Report: Soft endoscopic treatment of Herlyn-Werner-Wunderlich syndrome: an innovative clinical procedure for hymen preservation.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Herlyn-Werner-Wunderlich syndrome (HWWS) management typically requires hymenotomy. We describe the fully endoscopic, hymen-sparing septotomy in a patient with no history of sexual intercourse. Case presentation: A 20-year-old patient with no prior sexual intercourse and progressive dysmenorrhea was diagnosed by MRI with HWWS, presenting as uterus didelphys, obstructed right hemivagina, and left renal agenesis. A 9-mm flexible gastroscope and endoscopic submucosal dissection (ESD) knives were introduced through the intact hymen to resect an 11 × 13 mm oblique septum, evacuating 20 mL of chocolate fluid. The hymen remained intact. The patient was discharged on postoperative day 3 and remained asymptomatic at 2-month follow-up, with no residual hematocolpos detected on ultrasound. Telephone follow-up at 12 and 18 months postoperatively confirmed no recurrence of dysmenorrhea. Conclusion: Endoscopic septotomy safely relieves HWWS obstruction while preserving hymenal integrity in patients with no sexual history. This novel technique addresses a crucial patient-centered need and expands therapeutic options for complex Müllerian anomalies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.