ArticleFrontiers in neurology2026
Synaptic plasticity in affective comorbidities of neuropathic pain: a bibliometric analysis based on WoSCC and PubMed (2003-2025).
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Neuropathic pain (NP) is frequently accompanied by anxiety and depression, creating a vicious cycle that impairs quality of life. Synaptic plasticity-particularly long-term potentiation (LTP) and long-term depression (LTD)-is increasingly recognized as a shared neural substrate linking NP to affective comorbidities. This bibliometric analysis maps the research landscape at this intersection. Methods: Data were retrieved from the Web of Science Core Collection (January 1, 2003, to December 31, 2025) and PubMed (2003 to 2025). After deduplication and eligibility screening, a total of 487 unique publications were identified. Citation metrics and visualization analyses were performed using VOSviewer, CiteSpace, and Bibliometrix. Results: Publication output has grown steadily since 2003, peaking in 2025 (43 studies). China leads in publication count (180), while the United States holds the highest citation impact (9,723 citations; 64.82 per study). Air Force Medical University and the Xi'an Jiaotong University are core institutions. Conclusion: This bibliometric analysis maps a field advancing from single-region synaptic mechanisms toward multi-region circuit integration, with growing contributions from immunology. Persistent gaps in sex-difference characterization and longitudinal study design mark priorities for future investigation. As a descriptive exercise bounded by two databases, these findings should be weighed accordingly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.