Evidence map›Paper›PMID 42755559›Full record

ReviewFrontiers in cell and developmental biology2026

The use of

Madelyn Miles, Mert Karatas, Adrian Rothenfluh

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Madelyn MilesNeuroscience Graduate Program, University of Utah, Salt Lake City, UT, United States.
Mert KaratasDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, United States.
Adrian RothenfluhNeuroscience Graduate Program, University of Utah, Salt Lake City, UT, United States.

Funding

Dissemination of FlyWire, A Whole-Brain Connectomics ResourceU24NS126935 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2022 to 2026
$5.6M
Control of Alcohol Responses by Actin-Regulating GenesR01AA019526 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHENFLUH, ADRIAN · 2010 to 2025
$5.4M
Crowdsourcing the Fly ConnectomeRF1MH117815 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA, SEUNG, HYUNJUNE SEBASTIAN · 2018 to 2018
$3.3M
Transcriptional Regulation of Alcohol Sensitivity and ToleranceR01AA030881 · NIAAA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Adrian Rothenfluh · 2023 to 2026
$2.1M
Mechanisms of psychostimulant-sleep interactionsR01DA061298 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Adrian Rothenfluh · 2025 to 2026
$919k
Alcohol Tolerance as a Driver of Self-AdministrationR21AA031795 · NIAAA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ROTHENFLUH, ADRIAN · 2024 to 2025
$405k
Genetics of Amphetamine PreferenceR21DA060453 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ROTHENFLUH, ADRIAN · 2024 to 2025
$383k
NIAAA NIH HHS R01 AA019526NIAAA NIH HHS R01 AA030881NIAAA NIH HHS R21 AA031795NIDA NIH HHS R01 DA061298NIDA NIH HHS R21 DA060453NIMH NIH HHS RF1 MH117815NINDS NIH HHS U24 NS126935
6 · The paper itself

Abstract

Stimulant drugs like cocaine and methamphetamine acutely enhance the release of monoamine neurotransmitters, particularly dopamine, to induce euphoria, motivation, hyperlocomotion, and strong sleep suppression. Chronic stimulant use can lead to the development of stimulant use disorder (SUD), which is characterized by risky, excessive, or uncontrolled drug intake and an inability to cease use. At time of writing, there is no FDA-approved pharmacological treatment for SUD. Though symptoms and comorbidities of SUD vary, studies on abstinent stimulant-users repeatedly identify sleep disorder as a symptom that persists long into abstinence and drives relapse to stimulant use. This review discusses the use of the vinegar fly

Indexed as

addictiondopamineDrosophilapsychostimulantssleep

Identifiers

PMID42755559
PMCPMC13581550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.