ArticleFrontiers in immunology2026
Diabetes impairs antifungal immunity and drives fatal disseminated sporotrichosis in mice.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: This study establishes and characterizes a novel experimental mouse model to evaluate Methods: Diabetic and normoglycemic control mice were infected with Results: Diabetic mice exhibited enhanced susceptibility to infection compared to normoglycemic controls, presenting with progressive ulcerative lesions, systemic dissemination (lymph nodes, liver, and brain), and 100% mortality. This severe phenotype was accompanied by a dysregulated inflammatory profile, characterized by elevated systemic TNF-α, IFN-γ, and IL-6 alongside reduced splenic CD4+ T cell frequencies. Functionally, macrophages from diabetic hosts displayed an initial increase in yeast association followed by a rapid decline, consistent with cellular exhaustion. Additionally, infected diabetic mice exhibited hepatic accumulation of Discussion: Overall, this model successfully reproduces severe, disseminated sporotrichosis under hyperglycemic conditions and delineates the multifaceted immune dysregulation associated with host susceptibility. This novel experimental platform provides a valuable tool for future studies exploring fungal pathogenesis and therapeutic strategies in metabolic comorbidities.
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