Observational studyFrontiers in public health2026
Short-term metabolic changes during app-based dietary management in type 2 diabetes mellitus: a single-arm observational study with a separate Mendelian randomization analysis.
Observational study in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: We evaluated short-term metabolic changes during a structured app-based dietary management program in patients with type 2 diabetes mellitus (T2DM). In a separate analysis using independent genome-wide association study (GWAS) datasets, we examined the population-level association between genetically predicted liver fat and glycated hemoglobin (HbA1c). Methods: The clinical component was a prospective single-arm observational study of 103 adults with T2DM who received an individualized 4-week dietary prescription, recorded daily intake using a mobile application, and received weekly dietitian feedback. Anthropometric and laboratory measures were compared before and after the management period using paired tests. Associations between changes in glycemic and anthropometric indicators were assessed using Spearman correlation. The separate two-sample Mendelian randomization (MR) analysis used liver fat as the exposure and HbA1c as the outcome; inverse-variance weighted (IVW) analysis was primary. Results: Fasting blood glucose decreased from 7.26 ± 2.26 to 6.91 ± 2.08 mmol/L ( Conclusion: Glycemic measures were lower after the 4-week management period than at baseline, but the single-arm design prevents attribution of these changes specifically to the program. The visceral fat-HbA1c correlation was exploratory. The separate MR analysis addressed a distinct population-level question and did not provide confirmatory evidence in the primary analysis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.