Evidence map›Paper›PMID 42755292›Full record

ArticleRenal failure2026

Association between central thyroid hormone dysregulation and chronic kidney disease in type 2 diabetes: a cross-sectional study.

Heming Huang, Yanjia Shi, Ping Fang, Sijing Tang, Wei Xu, Chenxia Zhou, Yun Zhou, Keqin Zhang, Ying Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Heming HuangDepartment of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0009-0009-6062-9453
Yanjia ShiDepartment of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0001-5113-0508
Ping FangDepartment of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-3337-5752
Sijing TangDepartment of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0009-0002-3718-7625
Wei XuDepartment of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0009-0007-3235-2675
Chenxia ZhouDepartment of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0009-0006-5439-2515
Yun ZhouDepartment of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0009-0001-2888-2960
Keqin ZhangDepartment of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-6350-1393
Ying XueDepartment of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-6812-5665

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This cross-sectional study investigated the association between central thyroid hormone resistance and chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM) who have normal peripheral thyroid hormones. The study included 2,759 T2DM patients with normal serum free triiodothyronine (FT3) and free thyroxine (FT4) levels. Central thyroid sensitivity was quantified using the Thyroid Feedback Quantile-based Index (TFQI), thyrotrophic thyroxine resistance index (TT4RI), TSH Index (TSHI), and FT3/FT4 ratio. Utilizing multivariable logistic regression and restricted cubic splines (RCS), we found that elevated TSH levels and increased central thyroid hormone resistance (indicated by higher TFQI, TT4RI, and TSHI) were independently associated with an increased risk of CKD. Notably, RCS analysis revealed a significant non-linear relationship (

Indexed as

Diabetes Mellitus, Type 2Renal Insufficiency, ChronicThyroid HormonesThyrotropinAgedCross-Sectional StudiesFemaleHumansLogistic ModelsMaleMiddle AgedRisk FactorsThyroxineTriiodothyronineThyroid HormonesThyrotropinThyroxineTriiodothyronineCentral thyroid hormone resistancechronic kidney diseasethyroid stimulating hormoneType 2 diabetes mellitus

Identifiers

PMID42755292
PMCPMC13591943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.