Evidence map›Paper›PMID 42755286›Full record

ArticleAnnals of medicine2026

Effect of transcutaneous auricular vagus nerve stimulation on postoperative gastrointestinal dysfunction in patients with gynecological abdominal or pelvic tumors: a study protocol for a prospective, single-center, randomized, controlled clinical trial.

Mingxia Liu, Keyu Fan, Ya Cao, Lu Qian, Yuxuan Zhang, Danru Wu, Yunfeng Wang, Chongchun Dai, Qin Zhang, Ling Zhang and 5 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mingxia LiuDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.
Keyu FanDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.
Ya CaoDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.
Lu QianDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.
Yuxuan ZhangDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.
Danru WuDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.
Yunfeng WangDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.
Chongchun DaiDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.
Qin ZhangDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.
Ling ZhangDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.
Zhonghua LiDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.ORCID 0000-0001-9380-2130
Yu ShenDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.
Jingqiu WeiDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.
Xi YangDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China.
He LiuDepartment of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou central Hospital, The fifth school of clinical Medicine of Zhejiang chinese Medical University, Huzhou, Zhejiang Province, China.ORCID 0000-0002-4103-312X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative gastrointestinal dysfunction (POGD) commonly presents with nausea, vomiting, abdominal distension, delayed flatus or stool, and prolonged intolerance to oral intake. It can cause postoperative pain, delayed gastrointestinal motility, or intestinal obstruction requiring secondary surgery, imposing substantial physical, emotional, and economic burdens. Transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive brain-gut axis modulator, may promote postoperative gastrointestinal recovery. This study will assess the efficacy and safety of taVNS in reducing the incidence of POGD after gynecological abdominal or pelvic tumor surgery. METHODS AND ANALYSIS: This randomized, single-center, controlled trial will enroll 210 patients scheduled for gynecological abdominal or pelvic tumor surgery and randomly assign them 1:1 to taVNS or sham-taVNS (n = 105 each). The primary outcome is the incidence of POGD within three days after surgery, assessed by the Intake, Feeling nauseated, Emesis, Exam, and Duration of symptoms (I-FEED) scoring system. Secondary outcomes include time to first flatus, time to first bowel movement, incidence and severity of postoperative nausea and vomiting, time to first ambulation, time to first oral intake, incidence of postoperative delirium, and postoperative pain intensity. ETHICS AND DISSEMINATION: The Ethics Committee of Huzhou Central Hospital approved this study (approval no. 202503014-03). Findings will be disseminated at national anesthesiology conferences and published in peer-reviewed journals.

trial registrationChiCTR2500104412 (Chinese Clinical Trial Registry, http://www.chictr.org.cn; registered June 17, 2025).

Indexed as

Abdominal NeoplasmsGastrointestinal DiseasesGenital Neoplasms, FemalePelvic NeoplasmsPostoperative ComplicationsTranscutaneous Electric Nerve StimulationVagus Nerve StimulationAdultFemaleGynecologic Surgical ProceduresHumansIncidenceMiddle AgedPostoperative Nausea and VomitingProspective StudiesRandomized Controlled Trials as Topicgynecological abdominal or pelvic tumorspostoperative gastrointestinal dysfunctionTranscutaneous auricular vagus nerve stimulation

Identifiers

PMID42755286
PMCPMC13625528

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.