ArticleChemical biology & drug design2026
Synthesis, Structural Characterization, and Investigation of Biological Effects of Novel Benzothiazole-Triazole Derivatives Designed as AKT Kinase Inhibitors.
Article in Chemical biology & drug design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Breast cancer (BC) is one of the most common cancers in women worldwide, and the need for new, more effective treatment options remains. The PI3K/Akt signaling pathway and the aromatase enzyme are among the molecular targets that play a critical role in the development and progression of BC. In this study, novel benzothiazole-triazole derivatives were synthesized, and their structures were confirmed using NMR and HRMS analyses. The cytotoxic activities of the eight synthesized compounds in the MCF-7 BC cell line were evaluated using the MTT method, with NIH/3T3 cells used as a healthy cell model. The IC
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