Trial reportCancer imaging : the official publication of the International Cancer Imaging Society2026
Trial report in Cancer imaging : the official publication of the International Cancer Imaging Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05323890 (Neoadjuvant Tislelizumab Combined With Chemoradiotherapy for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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Neoadjuvant Tislelizumab Combined With Chemoradiotherapy for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma : Single Arm Phase II Study
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeoadjuvant immunotherapy plus chemoradiotherapy (nICRT) for esophageal squamous cell carcinoma (ESCC) received increasing attention because of high pathological complete response (pCR) rate. Accurately assessing residual disease after nICRT is beneficial for dynamic monitoring of patients. This exploratory, single-arm, phase II clinical study aimed to evaluate the diagnostic efficacy of
methodsFrom January 12, 2021 to February 21, 2023, a total of 21 resectable ESCC patients receiving nICRT were enrolled and underwent baseline PET/CT scans (scan-1) and surgery. 19 patients underwent scans (scan-2) before surgery. The recorded PET/CT parameters included maximum, mean, and peak standardized uptake values (SUVmax, SUVmean, and SUVpeak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). The diagnostic performance of PET/CT parameters was analyzed between the patients with pCR of the primary tumor (pCR-tu) and non-pCR-tu. The Cox regression and Kaplan-Meier method were performed for multivariable analysis and survival analyses, respectively.
results13(61.9%) achieved pCR-tu after nICRT among the 21 participants. None of the single metabolic parameters of primary tumor were significant predictors of pCR-tu (all p > 0.05). SUVmax2 of lymph nodes (Ln) has diagnostic value for lymph nodes metastasis (p < 0.01), the area under the curve (AUC), sensitivity and specificity were 0.812, 77.8% and 76.9%, respectively. The 3-year overall survival (OS) and disease-free survival (DFS) rates were 76.2% and 66.7%, respectively. Univariate Cox regression indicated that OS and DFS were correlated with the postoperative ypN stage, ypTNM stage, pCR, pCR-tu, SUVmax2, and LnSUVmax2. Long rank analysis showed that patients with a cutoff value of ≥12.4 for SUVmax2 and of ≥7.9 for LnSUVmax2 had poorer OS and DFS. However, multivariate Cox regression showed that the parameters mentioned above were not independent prognostic factors for OS and DFS.
conclusionsNone of the single metabolic parameters of the primary tumor were significant predictors of pCR-tu. LnSUVmax2 has diagnostic value for lymph nodes metastasis. The patients with SUVmax2 ≥ 12.4 and LnSUVmax2 ≥ 7.9 had poorer OS and DFS, but they are not independent prognostic factors, which needs to be confirmed by larger scale clinical studies.
trial registrationNCT05323890. Registered on April 5, 2022. Retrospectively registered.
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