Observational studyBMC pregnancy and childbirth2026
Prevalence, risk factors and adverse outcomes of intrapartum related asphyxia amongst newborns from mothers with low-risk deliveries in peri-urban Gambian health facilities: a retrospective cohort study.
Observational study in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03199547 (Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis and Death), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis and Death: a Phase III Double-blind Randomized Clinical Trial
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
introductionDespite significant progress in perinatal care, intrapartum-related asphyxia remains a leading cause of neonatal morbidity and mortality, especially in the poorest regions of the world such as sub-Saharan Africa. The objective of this study is to determine the prevalence, risk factors, and adverse outcomes of intrapartum-related asphyxia among low-risk health facility-based deliveries in The Gambia.
methodsThis is a secondary analysis of a randomised clinical trial conducted in western Gambia between October 2017 and May 2021. Women with low-risk pregnancies in labour and their live neonates were recruited at two public health facilities. The prevalence, risk factors, and neonatal outcomes of intrapartum-related asphyxia, defined as 1-min Apgar score < 7 were determined using descriptive methods, and unadjusted and adjusted logistic regression.
resultsAmong 6,758 neonates, 257 (3.8%) experienced intrapartum-related asphyxia, 93 (36.2%) of them required hospitalisation. The neonatal case fatality rate was 13.9% (34/245) among newborns with intrapartum-related asphyxia. Neonatal death (OR = 19.56, 95% CI:12.02-31.55, p-value < 0.001) and hospitalisation (OR = 11.91, 95% CI:8.90-15.90, p-value < 0.001) were significantly higher among these neonates. Severe intrapartum-related asphyxia cases had a significantly high risk for neonatal death (aOR:71.8, 95%CI, 36.00-140.40, p-value < 0.001) and hospitalisation (aOR:19.5, 95%CI, 10.80-35.00, p-value < 0.001); however, this risk remained considerable even in mild/moderate cases. Adjusted analysis revealed macrosomia as a major modifiable risk factor (aOR: 3.31, 95%CI, 1.78-6.15, p-value < 0.001), and several identifiable risk factors such as history of previous stillbirths (aOR: 2.79, 95%CI, 1.41-5.52, p-value = 0.003) or miscarriage (aOR: 1.65, 95%CI, 1.08-2.52, p-value = 0.02), and primiparity (aOR: 1.69, 95%CI, 1.16-2.46, p-value < 0.001).
conclusionsIntrapartum-related asphyxia is a major contributor to neonatal morbidity and mortality among low-risk pregnant women in peri-urban Gambia. A significant proportion of intrapartum-related asphyxia is preventable with timely identification of risk factors by improved antenatal and obstetric care followed by appropriate intrapartum management. Availability of adequate equipment, infrastructures, and skilled staff to help neonates breathe at birth are urgently required to reach the Sustainable Development Goal 3.2 of reducing by 2030 neonatal mortality to 12 deaths per 1000 live births.
trial registrationNCT03199547: Clinicaltrials.gov. Registered on 23rd June 2017. DOI: https://dx.doi.org/10.18203/2349-3259.ijct20220110 .
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.