Evidence map›Paper›PMID 42754856›Full record

ArticleBMC cancer2026

Profiling proteomic responses in small intestinal neuroendocrine tumor GOT1 after [

Johan K E Spetz, Mikael E Montelius, Evelin Berger, Julia A M Johansson, Nishte Rassol, Maria Ljungberg, Eva B Forssell-Aronsson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Johan K E SpetzDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gula Stråket 2B, 3rd floor, Sahlgrenska University Hospital, Gothenburg, SE-413 45, Sweden. johan.spetz@gu.se.ORCID http://orcid.org/0000-0002-5216-9786
Mikael E MonteliusDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gula Stråket 2B, 3rd floor, Sahlgrenska University Hospital, Gothenburg, SE-413 45, Sweden.ORCID http://orcid.org/0000-0001-9103-3446
Evelin BergerSciLifeLab, Proteomics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Julia A M JohanssonDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gula Stråket 2B, 3rd floor, Sahlgrenska University Hospital, Gothenburg, SE-413 45, Sweden.
Nishte RassolDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gula Stråket 2B, 3rd floor, Sahlgrenska University Hospital, Gothenburg, SE-413 45, Sweden.ORCID http://orcid.org/0009-0005-2982-3275
Maria LjungbergDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gula Stråket 2B, 3rd floor, Sahlgrenska University Hospital, Gothenburg, SE-413 45, Sweden.ORCID http://orcid.org/0000-0001-8991-2353
Eva B Forssell-AronssonDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gula Stråket 2B, 3rd floor, Sahlgrenska University Hospital, Gothenburg, SE-413 45, Sweden.ORCID http://orcid.org/0000-0002-7558-4368

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeptide receptor radionuclide therapy with [

methodsGOT1 tumor-bearing BALB/c nude mice received a non-curative intravenous administration of 15 MBq [

resultsTreatment induced a transient reduction in tumor volume followed by regrowth. In total, 3861 proteins were quantified, of which 155 showed significantly altered expression after treatment. Affected proteins were associated with cytoskeletal organization, oxidative stress response, protein metabolism, and systemic regulation. Pathway analyses identified inhibition of several signaling pathways linked to cell migration and invasiveness, including RhoA, Rac, integrin, and CXCR4 signaling. Upstream regulator analysis suggested activation of RABL6 and inhibition of p53 signaling during tumor regrowth. Proteins related to endoplasmic reticulum stress and ubiquitin-proteasome activity were also altered. Selected findings were validated by ELISA.

conclusions[

Indexed as

Intestinal NeoplasmsNeuroendocrine TumorsOctreotideOrganometallic CompoundsProteomeProteomicsAnimalsCell Line, TumorHumansIntestine, SmallMiceMice, Inbred BALB CMice, NudeXenograft Model Antitumor Assayslutetium Lu 177 dotatateOctreotideOrganometallic CompoundsProteomeGEPNETIonizing radiationLutatheraMass spectrometryPRRTRadiation biology

Identifiers

PMID42754856
PMCPMC13584284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.