ArticlePharmaceutical research2026
Insight Into the Role of Release Kinetics of Chemical Penetration Enhancer on Drug Diffusion in Drug-in-adhesive Patch.
Article in Pharmaceutical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeAs a key excipient in drug-in-adhesive patches, the diffusion behavior of chemical penetration enhancers (CPE) directly affects the diffusion behavior of drugs and thus determines whether the drug can achieve effective skin penetration. Therefore, the study of the release kinetics (RK) of CPE is pivotal.
methodsRK of five CPEs (Span 80 (Span), Isopropyl palmitate (IPP); Dipropylene Glycol (DPG); Menthol (MEN) and N-methyl-2-pyrrolidone (NMP)) and its effect on drug diffusion were researched by in vitro release study, in vitro skin penetration study, molecular dynamic simulation and Raman imaging. And the molecular mechanisms were characterized using modulated-temperature differential scanning calorimetry, rheology study, Fourier transform infrared spectroscopy and
resultsThe various RK behaviors of CPE enhanced the dynamic change in release rate (k) of drug at different degrees, and their RK parameters (k
conclusionsThe miscibility between CPE and the matrix (assessed by LogP
Indexed as
Identifiers
42754778What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.