Evidence map›Paper›PMID 42754730›Full record

ArticleNature metabolism2026

Effects of time-restricted eating in early-stage Huntington's disease: a pilot study.

Russell G Wells, Lee E Neilson, Andrew W McHill, Nora E Gray, Joseph F Quinn, Amie L Hiller

Registry-linked trialAbstract read
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In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06490367 (Safety, Feasibility, and Biomarker Effects of Time-restricted Eating for 12 Weeks in Early-stage Huntington's Disease.), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06490367 nacompletednot on this map

Safety, Feasibility, and Biomarker Effects of Time-restricted Eating for 12 Weeks in Early-stage Huntington's Disease.

TypeinterventionalSponsorOregon Health and Science UniversityRan2024 to 2025Enrolled22ConditionsHuntington DiseaseArmsTime-Restricted Eating Diet
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Russell G WellsDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA. wellsru@ohsu.edu.ORCID http://orcid.org/0000-0001-6534-7863
Lee E NeilsonDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Andrew W McHillSleep, Chronobiology, and Health Laboratory, School of Nursing, Oregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0002-9428-6884
Nora E GrayDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Joseph F QuinnDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Amie L HillerDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.

Funding

U.S. Department of Veterans Affairs (Department of Veterans Affairs) VA CSR&D CDA2 IK2 CX00253
6 · The paper itself

Abstract

Time-restricted eating (TRE) has shown neuroprotective potential in preclinical models of Huntington's disease (HD) but has not been tested clinically. Here, we report the results of a 12-week open-label pilot trial ( NCT06490367 ) of 8-h TRE, alongside standard-of-care diet and activity recommendations, in 20 individuals with early-stage HD. We show that TRE is feasible, well tolerated and associated with favourable changes in clinical measures of HD and plasma neurofilament light levels. Overall, these results support the need for further investigation of TRE as a potential lifestyle intervention in HD.

Identifiers

PMID42754730

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