Evidence map›Paper›PMID 42754660›Full record

ArticleEMBO molecular medicine2026

Microbiome-host communication via vaccenic acid modulates LRH-1/NR5A2 activity and ameliorates metabolic liver disease.

Anna Pia Plazzo, Verena Filz, Michaela Prothiwa, Rebekka Lambrecht, M Eugenia Delgado, Jennifer R Fleming, Jerome Duschek, Elia Pilgram, Juliane Friedrich, Raphael Eisenring and 8 more

Abstract read
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In one paragraph

Article in EMBO molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Anna Pia PlazzoBiochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.
Verena FilzDepartment of Microbiology and Ecosystem Science and Department of Biological Chemistry, University of Vienna, Vienna, Austria.
Michaela ProthiwaDepartment of Microbiology and Ecosystem Science and Department of Biological Chemistry, University of Vienna, Vienna, Austria.
Rebekka LambrechtBiochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.ORCID http://orcid.org/0000-0002-7717-1778
M Eugenia DelgadoBiochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.ORCID http://orcid.org/0000-0002-8653-1819
Jennifer R FlemingBiophysics and Structural Biology, Department of Biology, University of Konstanz, Konstanz, Germany.
Jerome DuschekBiochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.ORCID http://orcid.org/0009-0001-4276-5322
Elia PilgramBiochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.
Juliane FriedrichBiochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.
Raphael EisenringBiochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.
Lea KurtzBiochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.
Kerstin StemmerDivision of Molecular Cell Biology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.ORCID http://orcid.org/0000-0002-7526-2326
Lotta K StenmanDuPont Nutrition & Biosciences, Kantvik, Finland.
Fabian Amaya GarciaFraunhofer Institute for Silicate and University of Würzburg, Würzburg, Germany.
Miriam UnterlassFraunhofer Institute for Silicate and University of Würzburg, Würzburg, Germany.
Olga MayansBiophysics and Structural Biology, Department of Biology, University of Konstanz, Konstanz, Germany.ORCID http://orcid.org/0000-0001-6876-8532
Thomas BöttcherDepartment of Microbiology and Ecosystem Science and Department of Biological Chemistry, University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-0235-4825
Thomas BrunnerBiochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany. thomas.brunner@uni-konstanz.de.ORCID http://orcid.org/0000-0002-1594-4712

Funding

Deutsche Forschungsgemeinschaft (DFG) BR 3369/4-2
6 · The paper itself

Abstract

Interactions between microbiota and the host can profoundly affect human health. In particular, microbiota-derived metabolites influence liver physiology and contribute to the development of metabolic diseases, yet the molecular mechanisms underlying microbiome-host communication remain incompletely understood. Here, we identify bacterial lipids as modulators of the nuclear receptor Liver Receptor Homolog-1 (LRH-1/NR5A2), a regulator of hepatic metabolism. Lipid extracts from multiple bacterial species, including the probiotic Bifidobacterium animalis subsp. lactis B420

Identifiers

PMID42754660

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.