Evidence map›Paper›PMID 42754654›Full record

ArticleNature plants2026

Cross-ribbon conformation defines peptide recognition in SCREW/CTNIP-NUT/HSL3 signalling.

Xiaobin Wei, Mengyi Yao, Pingping Zhao, Xin Zhang, Kai Zhang, Wen Hu, Jiaqing Shi, Shuangyu Guo, Ruxin Li, Wei Wang and 4 more

Abstract read
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In one paragraph

Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaobin Wei *State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China.
Mengyi Yao *State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China.
Pingping Zhao *State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China.
Xin ZhangState Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China.
Kai ZhangState Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China.
Wen HuThe State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Jiaqing ShiState Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China.
Shuangyu GuoState Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China.
Ruxin LiState Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China.
Wei WangState Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China.ORCID http://orcid.org/0000-0002-4002-2648
Youwei XuThe State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0001-8069-7511
Siyi GuoState Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China. guosiyi@henu.edu.cn.ORCID http://orcid.org/0000-0003-2013-1772
H Eric XuThe State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. eric.xu@simm.ac.cn.ORCID http://orcid.org/0000-0002-6829-8144
Chun-Peng SongState Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China. songcp@henu.edu.cn.ORCID http://orcid.org/0000-0001-8774-4309

Funding

National Natural Science Foundation of China (National Science Foundation of China) U21A20206
6 · The paper itself

Abstract

Plants balance gas exchange with pathogen defense through dynamic stomatal regulation. Stomata close temporarily during pathogen attack to limit invasion, then reopen to restore photosynthesis and transpiration while lowering apoplast water saturation to inhibit pathogen proliferation. The secreted peptides, SCREW/CTNIP promote stomatal reopening through the receptor NUT/HSL3 and co-receptor BAK1/SERK3, thereby counteracting ABA and MAMP-triggered stomatal closure. Here we present the cryo-EM structures of AtNUTECD and the AtNUTECD-SCREW2/CTNIP4-AtBAK1ECD complex, uncovering a distinctive peptide-receptor interaction mechanism. SCREW2 adopts a unique cross-ribbon conformation that distinguishes it from other known conformations of LRR-RK-binding peptides, enabling its specific recognition by AtNUT and subsequent recruitment of AtBAK1. An N-linked glycan at N449 within the SCREW2-AtNUT binding interface is required for efficient SCREW2 recognition. Mutations in SCREW2 recognition sites significantly attenuated downstream MAPK activation and PTI marker gene expression.

Indexed as

ArabidopsisArabidopsis ProteinsPeptidesSignal TransductionCryoelectron MicroscopyProtein ConformationArabidopsis ProteinsPeptides

Identifiers

PMID42754654

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