Evidence map›Paper›PMID 42754619›Full record

ArticleNature communications2026

Hypoxia-activated scleraxis a mediates epicardial progenitor differentiation into a unique cardiac perivascular cell type.

Björn Perder, Yu Xia, Jun Yao, Ignace Van der Wee, Miaoyan Qiu, Alvin Gea Chen Yao, Muhammad Naeem, Paul Zumbo, Avi Yakubov, Stephanie L Tsai and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Björn Perder *Cardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Yu Xia *Cardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Jun YaoCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-7657-7170
Ignace Van der WeeCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Miaoyan QiuCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Alvin Gea Chen YaoCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Muhammad NaeemCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Paul ZumboApplied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.
Avi YakubovCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Stephanie L TsaiDepartment of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7549-3418
Kazu KikuchiDepartment of Cardiac Regeneration Biology, National Cerebral and Cardiovascular Center, Osaka, Japan.ORCID http://orcid.org/0000-0002-4681-4275
Jenna L GallowayDepartment of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Doron BetelApplied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8006-7752
Todd EvansCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-7148-9849
Michael R M HarrisonCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-1703-9879
Jingli CaoCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA. jic4001@med.cornell.edu.ORCID http://orcid.org/0000-0001-5938-6604

Funding

Mechanisms controlling epicardial-dependent promotion of heart regeneration in zebrafish.R01HL155607 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jingli Cao · 2021 to 2026
$2.9M
Spatiotemporal regulation of polyploidy in zebrafish cardiac tissue regenerationR01HL166518 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jingli Cao · 2023 to 2026
$2.8M
Lymphatic Support of Neurogenesis and RegenerationR01NS126209 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Michael Harrison · 2023 to 2026
$1.8M
American Heart Association (American Heart Association, Inc.) 23TPA1077772American Heart Association (American Heart Association, Inc.) AHA941434American Heart Association-American Stroke Association 941434NHLBI NIH HHS R01 HL155607NHLBI NIH HHS R01 HL166518NINDS NIH HHS R01 NS126209U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL155607U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL166518U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS126209
6 · The paper itself

Abstract

The epicardium provides progenitor cells and paracrine signals essential for heart development and regeneration, yet the mechanisms regulating epicardial cell fate remain poorly understood. Here, we identify the transcription factor Scleraxis a (scxa) as a key regulator of epicardial progenitor differentiation in zebrafish. Single-cell transcriptomics, genetic lineage tracing, and cardiac injury models reveal transient scxa expression in activated epicardial progenitor cells (aEPCs) during developmental coronary angiogenesis and heart regeneration. scxa

Indexed as

Basic Helix-Loop-Helix ProteinsCell DifferentiationHypoxiaPericardiumStem CellsZebrafish ProteinsAnimalsCoronary VesselsMesenchymal Stem CellsNeovascularization, PhysiologicRegenerationZebrafishBasic Helix-Loop-Helix ProteinsZebrafish Proteins

Identifiers

PMID42754619
PMCPMC13586233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.