Evidence map›Paper›PMID 42754617›Full record

ArticleNPJ Parkinson's disease2026

Coffee and Parkinson's disease: associations by CYP1A2 genotype and sex in UK Biobank.

Jieping Wang, Huanyu Wang, Kang Wan, Ruwen Wang, Shanshan Guo, Fuyi Ma, Yang Xiang, Hao Ma, Geng Zong, Xiao Zhi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jieping Wang *School of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Huanyu Wang *School of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Kang WanSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Ruwen WangSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Shanshan GuoSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Fuyi MaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Yang XiangMetabolic Control and Aging, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Province Key Laboratory of Aging and Disease, Nanchang, China.
Hao MaShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Geng ZongDepartment of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, Shanghai, China.
Xiao ZhiShanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaoli TianMetabolic Control and Aging, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Province Key Laboratory of Aging and Disease, Nanchang, China.
Guodong ZhouShanghai Yangpu District Kongjiang Hospital, Department of Stomatology, Shanghai, China. 18321801391@163.com.
Ru WangSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China. wangru@sus.edu.cn.

Funding

Shanghai Key Technology R&D Program: Medical Innovation Research Project 25Y42800200the National Natural Science Foundation of China 32571337
6 · The paper itself

Abstract

Coffee consumption has been associated with Parkinson's disease (PD), but findings remain inconsistent. We examined whether this association differs by CYP1A2 genotype and sex in 435,551 UK Biobank participants free of PD at baseline. During a median follow-up of 15.7 years, 3319 incident PD cases were identified. In overall analyses, coffee intake was not associated with PD risk. However, coffee intake significantly interacted with CYP1A2 genotype. Among AA carriers, coffee intake below 5 cups/day was associated with lower PD risk (HR 0.83, 95% CI 0.74-0.93), and spline analyses indicated a nonlinear association with the lowest risk at around 3 cups/day. In contrast, high coffee intake (≥5 cups/day) was associated with higher PD risk in AC carriers (HR 1.43, 95% CI 1.11-1.85) and CC carriers (HR 1.84, 95% CI 1.08-3.11). Sex-stratified analyses showed that the inverse association in AA carriers was more evident in women, whereas increased risk at high intake among AC/CC carriers was mainly observed in men. These findings support heterogeneity in the association between coffee intake and PD risk according to CYP1A2 genotype.

Identifiers

PMID42754617
PMCPMC13586350

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