Articlenpj aging2026
Age-related changes in olfactory function: electrophysiological recordings from the olfactory mucosa and human brain.
Article in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
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Abstract
Age-related olfactory decline in humans is well-documented, yet the underlying peripheral neural mechanisms remain poorly understood. We investigated age-related olfactory decline across psychophysical, nasal mucosal, and central neural levels in 73 healthy adults across the lifespan. Participants underwent Sniffin' Sticks testing and simultaneous recordings of mucosal electro-olfactograms (EOG) and cerebral chemosensory event-related potentials (CERP) in response to olfactory and trigeminal stimulation. Older adults exhibited significantly lower psychophysical olfactory scores, prolonged CERP P2 latencies, and reduced spectral power across theta, delta, and beta bands at peripheral (EOG) and cerebral (Fz, Cz, and Pz) sites. These findings demonstrate a systemic decline of olfactory function. Although the olfactory mucosa remains functionally active, diminished neural recruitment and oscillatory power, coupled with slower central processing, characterize olfactory aging. These objective electrophysiological markers provide a comprehensive profile of sensory decline in the aging population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.