Evidence map›Paper›PMID 42754575›Full record

ArticleNature communications2026

Advancing human-centric AI for robust X-ray analysis through holistic self-supervised learning.

Théo Moutakanni, Piotr Bojanowski, Guillaume Chassagnon, Céline Hudelot, Armand Joulin, Yann LeCun, Matthew Muckley, Maxime Oquab, Marie-Pierre Revel, Maria Vakalopoulou

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Mask of Truth: Model Sensitivity to Unexpected Regions of Medical Images.Journal of imaging informatics in medicine · 2026
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Théo MoutakanniFAIR at Meta, Paris, France. theo.moutakanni@gmail.com.ORCID http://orcid.org/0009-0000-2681-5169
Piotr BojanowskiFAIR at Meta, Paris, France.
Guillaume ChassagnonDepartment of Radiology, Hôpital Cochin, AP-HP. Centre Université Paris Cité, Paris, France.
Céline HudelotMICS, CentraleSupélec, Université Paris-Saclay, Gif-sur-Yvette, France.
Armand JoulinFAIR at Meta, Paris, France.
Yann LeCunFAIR at Meta, Paris, France.
Matthew MuckleyFAIR at Meta, Paris, France.
Maxime OquabFAIR at Meta, Paris, France.
Marie-Pierre RevelDepartment of Radiology, Hôpital Cochin, AP-HP. Centre Université Paris Cité, Paris, France.ORCID http://orcid.org/0000-0001-8213-7817
Maria VakalopoulouMICS, CentraleSupélec, Université Paris-Saclay, Gif-sur-Yvette, France. maria.vakalopoulou@centralesupelec.fr.

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-21-CE45-0007
6 · The paper itself

Abstract

Foundational artificial intelligence models are gaining traction in various applications, including medical fields like radiology. However, medical foundation models are often tested on limited tasks, leaving their generalisability and biases unexplored. Here we introduce RayDINO, a large-scale self-supervised visual encoder for chest X-rays trained on 840,000 images and evaluated on 82,000 images sourced from 12 publicly available datasets. We compare RayDINO to previous state-of-the-art models across nine radiology tasks, from classification and dense segmentation to text generation, and provide an in-depth analysis of population, age and sex biases of our model. Our findings suggest that self-supervision enables patient-centric analysis useful in clinical workflows, allowing for a more holistic interpretation of X-rays. With RayDINO and small task-specific adapters, we reach state-of-the-art results and improve generalization to unseen populations while mitigating bias, illustrating the versatility and robustness of foundation models.

Indexed as

Artificial IntelligenceRadiography, ThoracicSupervised Machine LearningAlgorithmsHumansX-Rays

Identifiers

PMID42754575
PMCPMC13586212

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.