Evidence map›Paper›PMID 42754554›Full record

ArticleNature communications2026

Carboxyl-directed, general α-site-selective deuteration of carboxylic acids by Pd

Juan Su, Xiang-Ting Min, Yike Huang, Xu Fang, Wen-Ting Zhang, Xunzhu Jiang, Boyu Yu, Wenjie Jiang, Xiaoli Pan, Lin Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Juan Su *State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
Xiang-Ting Min *State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. minxiangting@dicp.ac.cn.ORCID http://orcid.org/0000-0001-5400-4216
Yike Huang *Shanghai Smart Logic Technology Co., Ltd., Beijing, 100192, China.
Xu FangState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
Wen-Ting ZhangState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
Xunzhu JiangState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
Boyu YuState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
Wenjie JiangState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
Xiaoli PanState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
Lin LiState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
Botao QiaoState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. bqiao@dicp.ac.cn.ORCID http://orcid.org/0000-0001-6351-455X
Aiqin WangState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.ORCID http://orcid.org/0000-0003-4552-0360
Tao ZhangState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. taozhang@dicp.ac.cn.ORCID http://orcid.org/0000-0001-9470-7215

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22302199National Natural Science Foundation of China (National Science Foundation of China) 22310802000
6 · The paper itself

Abstract

Carboxylic acids are ubiquitous structural motifs in bioactive molecules, making their site-selective deuteration a powerful tool for probing biochemical mechanisms and improving the pharmacokinetic properties of drug molecules. Late-stage H/D exchange offers superiority over de novo synthesis from deuterated precursors, but remains challenging. Here, we report, to our knowledge, the first α-site-selective deuteration method that is compatible with both free amino acids and general (non-amino-acid) carboxylic acids enabled by a regenerable Pd

Identifiers

PMID42754554
PMCPMC13586253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.