Evidence map›Paper›PMID 42754384›Full record

ArticleLife science alliance2026

Drug-induced metabolic remodeling promotes antimicrobial activity in macrophages and extends longevity in vivo.

Claudia Hollmann, Eun Chan Park, Zheng Liu, Faye Nourollahi, Emīls Edgars Bašēns, Jonathan Dietz, Trushnal S Waghmare, Mehul Vora, Georgy Nikolayshvili, Nanci S Kane and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Claudia HollmannInstitute of Virology and Immunobiology, University of Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0002-3933-8370
Eun Chan ParkThe Waksman Institute, Rutgers The State University of New Jersey, Piscataway, NJ, USA.ORCID https://orcid.org/0000-0002-6147-4088
Zheng LiuInstitute of Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Faye NourollahiThe Waksman Institute, Rutgers The State University of New Jersey, Piscataway, NJ, USA.
Emīls Edgars BašēnsInstitute of Microbiology and Virology, Riga Stradiņš University, Riga, Latvia.ORCID https://orcid.org/0009-0006-8719-454X
Jonathan DietzThe Waksman Institute, Rutgers The State University of New Jersey, Piscataway, NJ, USA.
Trushnal S WaghmareInstitute of Microbiology and Virology, Riga Stradiņš University, Riga, Latvia.
Mehul VoraModOmics Ltd, Southampton, UK.
Georgy NikolayshviliInstitute of Microbiology and Virology, Riga Stradiņš University, Riga, Latvia.
Nanci S KaneThe Waksman Institute, Rutgers The State University of New Jersey, Piscataway, NJ, USA.
Tongbin LiAccuraScience, Johnston, IA, USA.
Fabian ImdahlHelmholtz Institute for RNA-based Infection Research, Würzburg, Germany.
Kay F MacleodThe Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Zaiga Nora-KrukleInstitute of Microbiology and Virology, Riga Stradiņš University, Riga, Latvia.ORCID https://orcid.org/0000-0002-0594-1091
Mohamed M ElashiryDepartment of Endodontics, Dental College of Georgia, Augusta University, Augusta, GA, USA.ORCID https://orcid.org/0000-0003-0880-4882
Christopher RongoThe Waksman Institute, Rutgers The State University of New Jersey, Piscataway, NJ, USA crongo@waksman.rutgers.edu.ORCID https://orcid.org/0000-0002-1361-5288
Bhupesh K PrustyInstitute of Virology and Immunobiology, University of Würzburg, Würzburg, Germany bhupesh.prusty@rsu.lv.ORCID https://orcid.org/0000-0001-7051-4670

Funding

Genetics Analysis of Neuronal Hypoxic Stress ResistanceR01GM101972 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI RONGO, CHRISTOPHER G · 2012 to 2024
$4.1M
Functions of BNIP3 in lipid metabolism in the liver and in hepatocellular carcinomaR01CA200310 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD · 2016 to 2026
$3.6M
Genetic Analysis of Hypoxic Stress ResistanceR35GM161506 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI Christopher G Rongo · 2026 to 2026
$616k
NCI NIH HHS R01 CA200310NIGMS NIH HHS R01 GM101972NIGMS NIH HHS R35 GM161506
6 · The paper itself

Abstract

Multiple immune mechanisms must be coordinated to defend against a broad range of pathogens; however, the mechanisms by which broad-spectrum antipathogens act remain largely elusive. Here, we used systems biology approaches to understand the organization of human immune cells at the single-cell level and their reorganization in response to K21, a silane derivative effective against viral, bacterial, and fungal infections. K21 effectively reduced the infectivity of

Indexed as

Anti-Infective AgentsLongevityMacrophagesAnimalsCaenorhabditis elegansEnterococcus faecalisHumansMitochondriaMitophagyPhagocytosisAnti-Infective Agents

Identifiers

PMID42754384
PMCPMC13586677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.