Salt Intake and Kidney Outcomes in Older Adults With Chronic Kidney Disease: A Stage-Specific Cohort Study.

Hiroaki Miyauchi, Tatsuhiko Azegami, Takashin Nakayama, Chisato Mitsue, Hirotaka Shibata, Kaori Hayashi

Abstract read

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Article in Nephrology (Carlton, Vic.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Hiroaki MiyauchiDivision of Nephrology, Endocrinology, and Metabolism, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0009-0003-2825-0482

Tatsuhiko AzegamiDivision of Nephrology, Endocrinology, and Metabolism, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-4809-5788

Takashin NakayamaDivision of Nephrology, Endocrinology, and Metabolism, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0003-2498-2793

Chisato MitsueDivision of Nephrology, Endocrinology, and Metabolism, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Hirotaka ShibataDepartment of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Oita, Japan.ORCID https://orcid.org/0000-0001-6506-4820

Kaori HayashiDivision of Nephrology, Endocrinology, and Metabolism, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-4923-1550

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimIn patients with chronic kidney disease (CKD), salt restriction has been shown to lower blood pressure and proteinuria and to provide kidney protective effects. However, the benefit of salt restriction in older adults with CKD remains unclear, particularly in advanced stages.

methodsWe conducted a single-center retrospective cohort study of patients aged ≥ 75 years with CKD (estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73 m

resultsA total of 462 patients (median age, 79 years; 68.6% male) were included. Of these, 305 had CKD Stage 3 and 157 had Stages 4-5. During a median follow-up of 2.79 years, 121 patients (26.2%) experienced the composite outcome. In Stage 3 CKD, higher salt intake was significantly associated with increased risk (adjusted HR 2.70; 95% CI 1.02-7.12; highest vs. lowest quartile), and findings were consistent across sensitivity analyses. In contrast, no significant association was observed in Stages 4-5.

conclusionAmong older adults with CKD, excessive salt intake was associated with adverse kidney outcomes in CKD Stage 3 but not in Stages 4-5. These results suggest that salt restriction may be most beneficial in the early stages of CKD in this population.

Indexed as

Diet, Sodium-RestrictedGlomerular Filtration RateKidneyRenal Insufficiency, ChronicSodium Chloride, DietaryAgedAged, 80 and overAge FactorsDisease ProgressionFemaleHumansMaleProportional Hazards ModelsRenal Replacement TherapyRetrospective StudiesRisk FactorsSodium Chloride, Dietarychronic kidney diseasekidney outcomeolder adultsalt intakesalt restriction

Identifiers

PMID42754360

DOI10.1111/nep.70285

PMCPMC13585483

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.