Evidence map›Paper›PMID 42753731›Full record

ArticleStem cell reports2026

Post-transcriptional regulation maintains neurogenic potential of human neural progenitor cells.

Natasha M Méndez-Albelo, Yajie Zhang, Soraya O Sandoval, Yu Guo, Yu Gao, Lily A Peters, Carissa L Sirois, Anna B Widicus, Paofue Yang, Drew N Trygstad and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Natasha M Méndez-AlbeloWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA; Molecular Cellular Pharmacology Training Program, University of Wisconsin-Madison, Madison, WI 53705, USA.
Yajie ZhangWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Soraya O SandovalWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA; Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI 53705, USA.
Yu GuoWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Yu GaoWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Lily A PetersWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Carissa L SiroisWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Anna B WidicusWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Paofue YangWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Drew N TrygstadWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Magnus T EckholmWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Zhiyan XuWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Graduate Program in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Riley V SmithWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Rachel M DisherWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Christian J JohnstonWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Xinyu ZhaoWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: xinyu.zhao@wisc.edu.

Funding

WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Brittany Gail Travers · 2021 to 2026
$8.5M
Graduate Training in Molecular and Cellular PharmacologyT32GM141013 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anjon Audhya, Aaron Matthew LeBeau · 2021 to 2026
$3.2M
The role of RNA binding protein in FXR1P in interneuronsR01MH118827 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI ZHAO, XINYU · 2019 to 2023
$2.2M
Interrogate FMRP functions in primate brain developmentR01MH136152 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Xinyu Zhao · 2024 to 2026
$2.2M
FMRP regulation of mitochondria and metabolism in mammalian brain developmentR01NS138268 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Xinyu Zhao · 2024 to 2026
$1.9M
Profiling cell type-specific ubiquitome in UBE3A mutant miceR21NS142497 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI GAO, YU · 2025 to 2025
$428k
Characterization of Fragile X Syndrome 3D Cortical OrganoidsR36MH136790 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI SANDOVAL, SORAYA OROZCO · 2024 to 2025
$91k
NICHD NIH HHS P50 HD103525NICHD NIH HHS P50 HD105353NIGMS NIH HHS T32 GM141013NIMH NIH HHS R01 MH118827NIMH NIH HHS R01 MH136152NIMH NIH HHS R36 MH136790NINDS NIH HHS R01 NS138268NINDS NIH HHS R21 NS142497
6 · The paper itself

Abstract

Increasing evidence supports important roles of post-transcriptional regulation in brain development; however, the precise mechanism remains unclear. Here, we show that Fragile X autosomal homolog 1 (FXR1), a brain-enriched RNA-binding protein (RBP), is essential for human neurogenesis. FXR1-deficient human cortical neural progenitor cells (NPCs) have reduced proliferation and impaired cell cycle exit during differentiation, leading to impaired neuronal differentiation. Transcriptomic and co-expression network analyses revealed FXR1 as an orchestrator of stage-specific gene programs driving neural differentiation. High-mobility group protein B2 (HMGB2), a master transcriptional regulator in stem cells, is a direct target of FXR1. FXR1 and HuR co-regulate HMGB2 mRNA, and their opposing actions on mRNA stability maintain the levels of HMGB2 in human NPCs. Reducing HMGB2 levels in FXR1-deficient NPCs rescues NPC proliferation and neuronal differentiation. Together, these findings establish post-transcriptional regulation as a key mechanism that maintains neurogenic potency of human NPCs.

Indexed as

Gene Expression RegulationNeural Stem CellsNeurogenesisRNA-Binding ProteinsRNA Processing, Post-TranscriptionalCell DifferentiationCell ProliferationELAV-Like Protein 1HMGB2 ProteinHumansRNA, MessengerRNA StabilityELAV-Like Protein 1FXR1 protein, humanHMGB2 ProteinRNA-Binding ProteinsRNA, MessengerFXR1HMGB2human pluripotent stem cellsHuRneural progenitor cellsneural stem cellsneurodevelopmentpost-transcriptional regulationRNA-binding protein

Identifiers

PMID42753731
PMCPMC13681417

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.