ArticleNeuron2026
Brainstem sensing of multiple body signals during food consumption.
Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Cellular coding of ingestion in the caudal brainstem.bioRxiv : the preprint server for biology · 2026Article
- Interoception network in the rat brain.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Ingestion-activated CGRP neurons control learning but not satiety.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
The peripheral neural pathways that relay oral and post-ingestive chemo- and mechanosensory signals to the brain during food consumption are increasingly well understood. Far less is known about how these and other body signals are integrated and organized in the brainstem lateral parabrachial nucleus (LPBN), a key interoceptive sensory hub. We established methods for dense calcium imaging of 100s of neurons from mouse LPBN. Food consumption drove a seconds-long wave of activity across LPBN, with dynamics mirroring the movement of food through the upper gastrointestinal tract as observed using X-ray videofluoroscopy. By imaging the same neurons across days, we found that spatially clustered subsets of neurons encoded oral signals, stomach filling, visceral malaise, arousal, and/or body movement. Moreover, only certain subsets were modulated by cortical input. Together, these experiments establish a platform for understanding how peripheral and central interoceptive signals are integrated in the brainstem to guide behavior.
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