ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2026
Folate-Targeted polymeric micelles enhance the anti-glioma efficacy of pterostilbene in an orthotopic rat model.
Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Betulinic acid alleviates ankylosing spondylitis and remodels Th17/Treg-associated immune landscapes revealed by single-cell transcriptomics.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
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21 authors.
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Abstract
The clinical translation of Pterostilbene, a neuroactive stilbene with broad therapeutic potential, is hampered by its poor aqueous solubility and insufficient brain accumulation. To address these limitations, we developed a folate receptor-targeted polymeric micelle system (F-Pt/M) using poly (ethylene glycol)-block-poly (ε-caprolactone) copolymers. The optimized F-Pt/M exhibited a small hydrodynamic diameter (∼133 nm), high drug loading, and increased the apparent solubility of pterostilbene by 25-fold. In folate receptor-expressing U251 and RG-2 glioma cells, F-Pt/M significantly enhanced cellular uptake via folate-mediated endocytosis and showed superior cytotoxicity compared to non-targeted micelles. In an orthotopic RG-2 glioma model, intravenous administration of F-Pt/M improved brain accumulation and prolonged median survival by 76.5% relative to free drug. Mechanistically, the enhanced anti-glioma efficacy was associated with induction of apoptosis and inhibition of the STAT3 signaling pathway. These findings establish folate-targeted micelles as a robust and versatile nanoplatform for delivering poorly soluble bioactive compounds to the brain, with pterostilbene representing a promising candidate for further neuro-oncological development.
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