Evidence map›Paper›PMID 42753217›Full record

ArticleJCO precision oncology2026

Exploring the Melanoma and Pancreatic Cancer Phenotype of a Potential

Daisy Hernandez, Ashlie Browning, Amber Gemmell, Karlena Lara-Otero, Mariana Niell-Swiller, Jacqueline Mersch, Kathryn A Mraz, Daniella Kamara, Amie Blanco, Yvonne Cardona and 12 more

Abstract read
In one paragraph

Article in JCO precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Daisy HernandezDepartment of Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA.ORCID 0000-0002-2473-5613
Ashlie BrowningHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA.
Amber GemmellSimmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0003-3824-2294
Karlena Lara-OteroCancer Genetics and Genomics Clinic, Stanford Medicine Healthcare, Stanford, CA.
Mariana Niell-SwillerCancer Genetics Services, University of California, Los Angeles (UCLA), Los Angeles, CA.
Jacqueline MerschSimmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX.
Kathryn A MrazDepartment of Genetics, Grey Genetics, Brooklyn, NY.ORCID 0000-0001-9824-8159
Daniella KamaraCancer Genetics Services, University of California, Los Angeles (UCLA), Los Angeles, CA.ORCID 0000-0003-4972-9292
Amie BlancoHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA.ORCID 0000-0003-3690-0038
Yvonne CardonaDepartment of Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA.ORCID 0009-0002-0987-3396
Emmeline ChangUSC Norris Comprehensive Cancer Center, Keck School of Medicine of USC, Los Angeles, CA.ORCID 0000-0002-9098-5522
Jacob G ComeauxDepartment of Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA.ORCID 0000-0002-0944-5079
Julie O CulverDepartment of Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA.ORCID 0000-0001-8658-3507
James M FordDepartment of Genetics and Department of Medicine, Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-2513-7025
Natalia GutierrezDepartment of Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA.ORCID 0009-0009-7275-6695
Jenny LesterCancer Genetics Services, University of California, Los Angeles (UCLA), Los Angeles, CA.
Beth Y KarlanCancer Genetics Services, University of California, Los Angeles (UCLA), Los Angeles, CA.ORCID 0000-0002-9451-2933
Ming LiUSC Norris Comprehensive Cancer Center, Keck School of Medicine of USC, Los Angeles, CA.ORCID 0009-0007-4563-6917
Qi NieUSC Norris Comprehensive Cancer Center, Keck School of Medicine of USC, Los Angeles, CA.ORCID 0009-0005-1165-7782
Jesus ResendizDepartment of Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA.ORCID 0009-0009-4436-6067
Maria L WeiHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA.ORCID 0000-0002-3568-1921
Charité N RickerDepartment of Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA.ORCID 0000-0002-0620-9345

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
UT Southwestern Center for Translational MedicineUL1TR003163 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2021 to 2025
$39.3M
NCATS NIH HHS UL1 TR003163NCI NIH HHS P30 CA014089
6 · The paper itself

Abstract

purposePathogenic/likely pathogenic variants (P/LPVs) in the

methodsInstitutional clinical databases were queried for the

resultsData on 203 individuals, with qualifying

conclusionIn the largest I49T study to date to our knowledge, MEL was significantly less frequent compared with known

Indexed as

Cyclin-Dependent Kinase Inhibitor p16MelanomaMexican AmericansPancreatic NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedPhenotypeCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16

Identifiers

PMID42753217
PMCPMC13600356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.