Evidence map›Paper›PMID 42753071›Full record

ReviewInflammopharmacology2026

Natural killer cells in ovarian cancer therapy: mechanisms, evasion, and therapeutic innovations.

Weihong Long, Caiyun Zhang, Can Zhang, Junjie Ni, Chao Xiong, Xu Wu, Mingxing Li, Fukuan Du, Yu Chen, Yueshui Zhao and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Weihong Long *Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Caiyun Zhang *Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Can Zhang *Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Junjie NiLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Chao XiongLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Xu WuLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Mingxing LiLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Fukuan DuLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Yu ChenLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Yueshui ZhaoLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Jing ShenLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Chi Hin ChoLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China. chcho@cuhk.edu.hk.
Zhangang XiaoLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China. zhangangxiao@swmu.edu.cn.ORCID https://orcid.org/0000-0003-4265-5833

Funding

Luzhou Science and Technology Plan Project 2023SYF107National Natural Science Foundation of China No. 82172962
6 · The paper itself

Abstract

Ovarian cancer, one of the most prevalent and formidable malignant tumours within the female reproductive system, poses a grave threat to women's health and lives. Although the current standard-of-care treatments-including cytoreductive surgery and platinum-based chemotherapy, supplemented by maintenance therapy with anti-angiogenic agents and poly (ADP-ribose) polymerase (PARP) inhibitors, can alleviate the disease to a certain extent, they face significant limitations, such as resistance to chemotherapeutic drugs, toxicity to normal tissues, and recurrence of the tumour. In contrast, natural killer (NK) cells, as an important part of the body's immune system, have anti-tumour activities, and their interaction with ovarian cancer cells to kill ovarian cancer cells brings new hope for cell therapy. The aim of this paper is to summarize the mechanisms involved in NK cells in ovarian cancer treatment, the current status of clinical applications, and new research strategies in the future, with the aim of providing a reference for the development of research and clinical practice in this field.

Indexed as

CAR-NKImmune evasionImmunological synapseNK cellsNKG2DOvarian cancer

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.