Evidence map›Paper›PMID 42753069›Full record

ArticleInflammopharmacology2026

Liposomal curcumin nanocarrier ameliorates synaptic dysfunction after intracerebral hemorrhage.

Kianoush Saberi, Nikki Ghadiminia, Abdumalik Mamataliyev, Telmon Turaev, Gulbahor Umarkulova, Otabek Nadjmitdinov, Abdukakhkhor Artikov, Sadridin Eshkaraev, Yuldash Takhirov, Barno Amirullayeva and 3 more

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Article in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Kianoush SaberiDepartment of Anesthesiology, Medical Faculty, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. laftaalihussein@gmail.com.ORCID http://orcid.org/0000-0002-4292-2252
Nikki GhadiminiaSchool of Psychology, University of Kent, Canterbury, UK.
Abdumalik MamataliyevDepartment of Fundamental Medical Sciences, Kimyo International University in Tashkent Samarkand Branch, Samarkand, Uzbekistan.
Telmon TuraevBukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Uzbekistan.
Gulbahor UmarkulovaJizzakh State Pedagogical University, Jizzakh, Uzbekistan.
Otabek NadjmitdinovDepartment of the Medical radiology and clinical-laboratory diagnostics, Andijan State Medical Institute, Andijan, Uzbekistan.
Abdukakhkhor ArtikovAndijan State University, Andijan, Uzbekistan.
Sadridin EshkaraevDepartment of Medicine, Termez University of Economics and Service, Termez, Uzbekistan.
Yuldash TakhirovDepartment of Chemistry, Urgench State University named after Abu Rayhan Biruni, Urgench, Uzbekistan.
Barno AmirullayevaDepartment of Pedagogy, University of Economics and Pedagogy, Karshi, Uzbekistan.
Nargiza AyubovaTashkent State Medical University, Tashkent, Uzbekistan.
Rano KuchkorovaNizami Tashkent State Pedagogical University, Tashkent, Uzbekistan.
Zamira ErdanovaTermez State Pedagogical Institute, Termez, Uzbekistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuroinflammation and synaptic dysfunction in the medial prefrontal cortex (mPFC) contribute to cognitive impairment after intracerebral hemorrhage (ICH). Curcumin, a natural polyphenol from Curcuma longa, has anti-inflammatory properties but limited bioavailability.

methodsLiposomal curcumin (Lipo-Cur, 103.2 nm, 74% encapsulation) was prepared by thin-film hydration. Adult male rats were assigned to Sham, ICH (collagenase + empty liposomes), and ICH-Cur (collagenase + Lipo-Cur, 30 mg/kg, i.p. at 2, 24, 48 h post-surgery). On day 7, we assessed NLRP3/caspase-1 inflammasome activation, BDNF/TrkB/CREB/Erk signaling, PSD-95 expression, neuronal survival (Nissl staining), and working memory (Y-maze).

resultsLipo-Cur significantly suppressed NLRP3/caspase-1, restored p-CREB/CREB and p-TrkB/TrkB, normalized p-Erk/Erk, and upregulated PSD-95 (all p < 0.01). It also reduced neuronal loss, restored BDNF (p < 0.05), attenuated NLRP3 (p < 0.01), and improved Y-maze alternation (p < 0.001) without affecting locomotion.

conclusionThese findings suggest that liposomal curcumin exerts neuroprotective effects in the mPFC after ICH, likely through mechanisms involving suppression of NLRP3/caspase-1 and enhancement of BDNF/TrkB/CREB signaling. This supports its potential as a natural product-based therapeutic for stroke-induced cognitive impairment, though further mechanistic studies are warranted.

Indexed as

Cerebral HemorrhageCurcuminNanoparticlesSynapsesAnimalsBrain-Derived Neurotrophic FactorDisease Models, AnimalInflammasomesLiposomesMaleMaze LearningNeuroprotective AgentsNLR Family, Pyrin Domain-Containing 3 ProteinPrefrontal CortexRatsRats, Sprague-DawleyBrain-Derived Neurotrophic FactorCurcuminInflammasomesLiposomesNeuroprotective AgentsNLR Family, Pyrin Domain-Containing 3 ProteinBDNF/TrkB signalingCurcuminIntracerebral hemorrhageLiposomal formulationNeuroinflammationNLRP3 inflammasome

Identifiers

PMID42753069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.