ArticleGeroScience2026
Mediating role of depressive symptoms in the association between trajectories of instrumental activities of daily living and all-cause mortality in middle-aged or older adults: a cohort study in South Korea.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to independently perform instrumental activities of daily living (IADL) is important for the quality of life and social activities among older adults. This study examined the association between IADL trajectories and all-cause mortality and the mediating role of depressive symptoms. A total of 6033 participants aged ≥ 45 years were included. Longitudinal trajectories of IADL limitation, assessed using the Korean Instrumental Activities of Daily Living from 2006 to 2014, were clustered through group-based trajectory modeling. Depressive symptoms were determined by the 10-item Center for Epidemiologic Studies-Depression Scale. The associations between IADL limitation trajectories and all-cause death until 2024 were determined using Cox regression analyses. A mediation analysis was performed to assess the mediating role of depressive symptoms in this association. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated. Two distinct trajectories of IADL limitation were identified: stable low (n = 5757; 95.4%) and increasing (n = 276; 4.6%). The trajectory of increasing IADL limitations was associated with elevated risk for all-cause mortality (adjusted HR = 2.13; 95% CI = 1.79-2.52) compared to the trajectory of stable-low IADL limitations. Mediation analysis indicated that depressive symptoms partially explained the association between the increasing IADL limitation trajectory and all-cause mortality (adjusted indirect HR = 1.09; 95% CI = 1.05-1.15), with a proportion mediated of 16.0% (95% CI = 9.7-23.8). This longitudinal mediation analysis revealed that individuals experiencing an increasing trajectory of IADL limitations exhibited a higher risk of all-cause mortality, with depressive symptoms partially accounting for this association.
Indexed as
Identifiers
42753032What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.