Evidence map›Paper›PMID 42753017›Full record

ArticleNeurochemical research2026

Enhanced HCN-Dependent Regulation of Temporoammonic Integration and Entorhinal-Hippocampal Epileptiform Coupling Following Febrile Seizures.

Georgy P Diespirov, Tatyana Y Postnikova, Dmitry V Amakhin, Elena B Soboleva, Anna A Kovalenko, Aleksey V Zaitsev

Abstract read
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In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Georgy P DiespirovSechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Saint Petersburg, 194223, Russia.
Tatyana Y PostnikovaSechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Saint Petersburg, 194223, Russia.
Dmitry V AmakhinSechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Saint Petersburg, 194223, Russia.
Elena B SobolevaSechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Saint Petersburg, 194223, Russia.
Anna A KovalenkoSechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Saint Petersburg, 194223, Russia.
Aleksey V ZaitsevSechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Saint Petersburg, 194223, Russia. aleksey_zaitsev@mail.ru.ORCID http://orcid.org/0000-0002-4503-0647

Funding

Russian Science Foundation 24-15-00293
6 · The paper itself

Abstract

Mechanisms linking early-life developmental pathologies, such as cortical malformations and febrile seizures (FS), to persistent hippocampal circuit alterations remain incompletely understood. We investigated intrinsic excitability, HCN channel function, pathway-specific synaptic integration, and entorhinal-hippocampal network activity using rat models of focal freeze lesion (FFL) at postnatal day (P) 0, experimental FS at P10, and their combination (FFL + FS). Whole-cell recordings at P21-23 showed that FFL predominantly reduced CA1 neuronal excitability, whereas the FS condition was associated with increased hyperpolarization-activated cation current (I

Indexed as

Entorhinal CortexHippocampusHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPotassium ChannelsSeizures, FebrileAnimalsMaleRatsHcn1 protein, ratHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPotassium ChannelsEntorhinal cortexEpileptiform activityFebrile seizuresHCN channelsHippocampusTemporoammonic pathway

Identifiers

PMID42753017

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.