Evidence map›Paper›PMID 42752627›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026

Probing novel azole-sulfonamide urea/thiourea conjugates as multitarget inhibitors of AChE and hCAs (I and II): synthesis, in vitro, and in silico studies.

İrfan Çapan, Çağan Yasa, Yeliz Demir, Metin Güzelcan, Mohammed T Qaoud, Yusuf Sert, İrfan Koca, İlhami Gülçin

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Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

İrfan ÇapanFaculty of Pharmacy, Department of Pharmaceutical Basic Sciences, Gazi University, Ankara, 06560, Turkey. irfancapan@gazi.edu.tr.ORCID http://orcid.org/0000-0002-9555-1555
Çağan YasaGraduate School of Natural and Applied Sciences, Department of Advanced Technologies, Gazi University, Ankara, 06330, Turkey.
Yeliz DemirDepartment of Pharmacy Services, Ardahan University, Nihat Delibalta Göle Vocational High School, Ardahan, 75000, Turkey.
Metin GüzelcanSente Kimya Research and Development Inc, Ankara, 06200, Turkey.
Mohammed T QaoudFaculty of Pharmacy, Department of Pharmacy, Cyprus International University, 99258, Northern Cyprus, Turkey.
Yusuf SertSorgun Vocational School, Yozgat Bozok University, Yozgat, 66700, Turkey.
İrfan KocaDepartment of Chemistry, Faculty of Art & Sciences, Yozgat Bozok University, Yozgat, 66100, Turkey.
İlhami GülçinFaculty of Science, Department of Chemistry, Atatürk University, Erzurum, 25240, Turkey.

Funding

Gazi Üniversitesi FGA-2024-9094
6 · The paper itself

Abstract

A series of 30 novel azole-sulfonamide urea and thiourea conjugates was rationally designed and synthesized as potential multitarget inhibitors of acetylcholinesterase (AChE) and the human carbonic anhydrase isoforms hCA I and hCA II. The molecular design combined azole-based heterocyclic scaffolds with the classical sulfonamide zinc-binding pharmacophore through urea or thiourea linkers. The synthesized compounds were characterized by FT-IR,

Indexed as

AcetylcholinesteraseAzole derivativesEnzyme inhibitionHuman carbonic anhydraseMolecular dockingSulfonamides

Identifiers

PMID42752627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.