Evidence map›Paper›PMID 42751910›Full record

ReviewZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

[Chemotherapy-related central nervous system injury in children with acute lymphoblastic leukemia: research progress].

Lei Wang, Nan-Ping Shen, Si-Yao Shi, Miao DU, Jia-Qing Yan, Ying Jiang

Abstract readReviewEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Review in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lei WangSchool of Nursing and Health Management, Shanghai University of Medicine & Health Sciences, Shanghai 201218, China.
Nan-Ping Shen
Si-Yao ShiSchool of Nursing and Health Management, Shanghai University of Medicine & Health Sciences, Shanghai 201218, China.
Miao DUSchool of Nursing and Health Management, Shanghai University of Medicine & Health Sciences, Shanghai 201218, China.
Jia-Qing YanSchool of Nursing and Health Management, Shanghai University of Medicine & Health Sciences, Shanghai 201218, China.
Ying JiangSchool of Nursing and Health Management, Shanghai University of Medicine & Health Sciences, Shanghai 201218, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Although therapeutic advances have markedly improved survival, chemotherapy-related central nervous system (CNS) injury is increasingly recognized as a major determinant of neurofunctional outcomes and quality of life. This review summarizes the clinical manifestations, imaging characteristics, and biomarker-based approaches to diagnosing chemotherapy-related CNS injury in children with ALL; outlines drug-induced neurotoxic mechanisms; and discusses current therapeutic and supportive interventions alongside persistent management challenges. There is no standardized, stage-specific care pathway or integrated intervention program at present. Future strategies should align prevention and management with treatment phase and chemotherapy regimen to achieve more precise CNS protection. This review aims to provide information for clinical healthcare professionals to deepen their understanding of the mechanisms, identification, and long-term management of chemotherapy-related CNS injury in children with ALL.

Indexed as

Antineoplastic AgentsCentral Nervous SystemPrecursor Cell Lymphoblastic Leukemia-LymphomaChildHumansAntineoplastic AgentsAcute lymphoblastic leukemiaCentral nervous systemChemotherapyChildNeurotoxicity

Identifiers

PMID42751910
PMCPMC13584599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.