ArticleEuropean journal of preventive cardiology2026
Heterogeneity in Lipoprotein(a) Profile Changes Across the Menopausal Transition.
Article in European journal of preventive cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimAssess changes in Lp(a) levels and transitions across ASCVD risk-thresholds by menopausal trajectory to inform risk stratification and testing recommendations. .
methodsWe examined changes in Lp(a) between visits 1 and 2 among UK Biobank women. Analyses were examined by menopausal trajectory: those who underwent menopause (N=415), those who remained premenopausal (N=532), and those who remained postmenopausal (N=3,615) between visits. Change in Lp(a) between visits was also stratified by visit 1 Lp(a). The primary outcome was incident Lp(a) ≥125 nmol/L at visit 2, estimated using Poisson regression.
resultsData were available for 4,562 women (mean visit 1 age = 57 years; median visit 1 Lp(a) = 22 nmol/L; median time between visits = 4 years). At visit 1, median Lp(a) was 23 nmol/L in postmenopausal women and 19 nmol/L in premenopausal women. Overall, median changes in Lp(a) between visits were modest. Among women with intermediate visit 1 Lp(a) (75-125 nmol/L), those who transitioned through menopause experienced a median increase of 34.9 nmol/L, approximately fourfold greater than women who remained pre- or postmenopausal. Further, 22 of 39 (56%) of women with intermediate visit 1 Lp(a) who had menopause between visits had incident Lp(a) ≥125 nmol/L at visit 2, compared with 29% and 28% of women who remained pre- or postmenopausal, representing a risk ratio of 2.27 (95% CI: 1.36, 3.78) after adjustment for visit 1 age and continuous Lp(a).
conclusionsRelying on a single lifetime Lp(a) measurement may miss reclassification across risk-enhancing thresholds during menopause, particularly for women with intermediate premenopausal levels.
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