ArticleCell biomaterials2026
PEG-lipid shedding and biodistribution are shaped by nanocarrier morphology and lipid chemistry.
Article in Cell biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Chemical and Biological Determinants of PEG-Lipid Shedding From Therapeutic Nanoparticles.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Surface chemistry governs sex-dependent responses to PEG and zwitterionic siRNA nanocarriers in primary macrophages.Science advances · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Targeting moieties are often attached to nanocarriers (NCs) using poly(ethylene glycol)-lipids (PEG-lipids) to direct uptake to target cells and organs. However, nanoparticles (NPs) can interact with proteins during systemic circulation, causing PEG-lipids to dissociate or "shed," which limits targeting efficiency. Here, we investigate how lipid chemistry and poly(ethylene glycol)-b-poly(propylene sulfide) (PEG-PPS) NC morphology affect PEG-lipid shedding. We conjugated one fluorophore to the NC and another to the PEG-lipid to track shedding over time. By coupling Förster resonance energy transfer (FRET) and total internal reflection fluorescence microscopy (TIRF) with biological systems, we found that PEG-lipids with stable anchors shed slowly and are consistent across NC morphologies. In contrast, weakly anchored PEG-lipids exhibit morphology-dependent shedding and biodistribution
Identifiers
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Registered trials
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