ArticleJournal of oral microbiology2026
Laminin functionalization of zirconia abutments modulates early oral biofilm formation in vitro.
Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Surface properties of dental implant abutment materials critically influence supragingival biofilm formation by determining the outcome of the early 'race for the surface', in which gingival epithelial cells and fibroblasts compete with bacteria for initial adhesion. This study hypothesized that biofunctionalization with extracellular matrix (ECM) proteins fibronectin (FN) or laminin (LN) modulates early oral biofilm formation on titanium alloy (Ti6Al4V) and yttria-stabilized zirconia (Y-TZP) abutments. Methods: Saliva-derived microcosm biofilms were grown on control and biofunctionalized discs. Biofilm biomass, viability, structure, microbial community composition and metabolic activity were assessed using microscopy-based methods, impedance flow cytometry, 16S rRNA sequencing and short-chain fatty acid analysis. Results: Laminin-functionalized Y-TZP showed the most pronounced delay in early biofilm formation. Biofilm accumulation was delayed during the first three days and was associated with the lowest number of viable cells on day 4, minimal extracellular polymeric substance formation, reduced Conclusion: ECM-based coatings do not exert bactericidal effects but transiently reshape early oral biofilm formation. Laminin-functionalized zirconia may act as a biologically selective interface that favors beneficial early host-microbe interactions, potentially creating a microbial environment more compatible with peri-implant soft-tissue health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.