Evidence map›Paper›PMID 42751573›Full record

ArticleAlzheimer's & dementia. Behavior & socioeconomics of aging2026

Cohort profile: a community-based prospective cohort study of Alzheimer's disease and related dementias in the Democratic Republic of Congo.

Jean Ikanga, Caterina Obenauf, Saranya Sundaram Patel, Megan Schwinne, Guy Gikelekele, Emmanuel Epenge, Japhet Magolu Potshi, Topina Tomadia, Julie Kazadi, Immaculee Kavugho and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia. Behavior & socioeconomics of aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Jean IkangaDepartment of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Caterina ObenaufDepartment of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Saranya Sundaram PatelDepartment of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Megan SchwinneSchool of Medicine, Department of Biomedical Informatics, Emory University, Atlanta, Georgia, USA.
Guy GikelekeleDepartment of Psychiatry, School of Medicine, University of Kinshasa and Catholic University of Congo, Kinshasa, Democratic Republic of Congo.
Emmanuel EpengeDepartment of Neurology, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Japhet Magolu PotshiDepartment of Neurology, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Topina TomadiaMemory Clinic of Kinshasa, Kinshasa, Democratic Republic of Congo.
Julie KazadiMemory Clinic of Kinshasa, Kinshasa, Democratic Republic of Congo.
Immaculee KavughoMemory Clinic of Kinshasa, Kinshasa, Democratic Republic of Congo.
Giovanni Luamba SantoliniMemory Clinic of Kinshasa, Kinshasa, Democratic Republic of Congo.
Aristote NkosiMemory Clinic of Kinshasa, Kinshasa, Democratic Republic of Congo.
Francine Manyonga SabowaMemory Clinic of Kinshasa, Kinshasa, Democratic Republic of Congo.
Brenda Matungu MusewuMemory Clinic of Kinshasa, Kinshasa, Democratic Republic of Congo.
Elipsis MawisaMemory Clinic of Kinshasa, Kinshasa, Democratic Republic of Congo.
Joseph Phuati TsanguDepartment of Anesthesiology and Reanimation, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Francis Muena Kondo BeyaDepartment of Anesthesiology and Reanimation, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Samuel MampunzaDepartment of Psychiatry, School of Medicine, University of Kinshasa and Catholic University of Congo, Kinshasa, Democratic Republic of Congo.
Lelo ManangaDepartment of Neurology, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Justine BukabauDepartment of Internal Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Charlotte E TeunissenAmsterdam University Medical Centers, Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Neurodegeneration, Amsterdam University Medical Centers, Vrije Universitiet, Amsterdam, the Netherlands.
Thomas KarikariDepartment of Psychiatry, School of Medicine, University of Pittsburg, Pittsburg, Pennsylvania, USA.
Alden L GrossDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Julio C RojasMemory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of San Francisco, San Francisco, California, USA.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI Jonathan David Glass · 2020 to 2026
$29.0M
NCATS NIH HHS UL1 TR002378NIA NIH HHS P30 AG066511
6 · The paper itself

Abstract

introductionThe Étude du Vieillissement Cognitif et de Démence en République Démocratique du Congo (EVCD-RDC) launched in 2024 to investigate socioenvironmental and biological determinants of dementia in Kinshasa.

methodsThe study recruited 1000 adults aged ≥65 years across four diagnostic groups - cognitively unimpaired (CU), mild cognitive impairment (MCI), Alzheimer's disease (AD), and other dementias (OD) - through community and clinical settings. Participants complete neuropsychological, neurological, social, and environmental assessments with biennial follow-up.

resultsTo date, 506 individuals have enrolled (mean age 73.4; 59.3% women), including 70 CU, 136 MCI, 120 AD, and 180 with OD. Dementia cases show higher rates of hypertension, comorbidities, neuropsychiatric symptoms, smoking, and alcohol use, along with lower body weight, education, and resilience, and greater exposure to pollution, conflict, trauma, and poverty. DISCUSSION: EVCD-RDC is the first large-scale dementia cohort in French-speaking sub-Saharan Africa and will provide critical longitudinal insights into modifiable risks, infectious diseases, and multi-omics in the region.

Indexed as

Alzheimer’s diseasebiomarkerscohort studydementiaDemocratic Republic of Congo

Identifiers

PMID42751573
PMCPMC13580453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.