ArticleGeburtshilfe und Frauenheilkunde2026
Maternal Malignancies Identified Through Non-invasive Prenatal Testing: A Systematic Review and Meta-Analysis.
Article in Geburtshilfe und Frauenheilkunde, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Objective: Non-invasive prenatal testing (NIPT) may incidentally reveal chromosomal abnormalities of maternal origin. Although specific chromosomal aberrations have been associated with maternal malignancy, reported risks vary widely. This meta-analysis aimed to quantify the magnitude and consistency of these associations. Methods: A systematic review and meta-analysis of observational studies reporting maternal malignancy among pregnant individuals with abnormal NIPT results was conducted. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a random-effects model. Risk of bias was assessed using the ROBINS-I tool. Results: Six studies met the inclusion criteria. Multiple chromosomal aberrations (MCA), although representing a minority of abnormal NIPT findings, accounted for a substantial proportion of confirmed maternal malignancies. MCA were strongly associated with cancer (OR 239.98; 95% CI 80.16-718.44; I Conclusion: Multiple chromosomal aberrations and complex gain-loss patterns on NIPT were strongly associated with maternal malignancy. These findings support the use of structured diagnostic pathways and targeted clinical evaluation when high-risk genomic patterns are identified.
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