Evidence map›Paper›PMID 42751347›Full record

ArticleInternational journal of pharmaceutics: X2026

Multifunctional TPU-HAp/HA-TiO

Eleonora Bianchi, Marco Ruggeri, Barbara Vigani, Carmela Tommasino, Elisabetta Maffioli, Pietro Grisoli, Cinzia Boselli, Antonia Icaro Cornaglia, Silvia Rossi, Giuseppina Sandri

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In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eleonora BianchiDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Marco RuggeriDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Barbara ViganiDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Carmela TommasinoDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Elisabetta MaffioliDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Pietro GrisoliDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Cinzia BoselliDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Antonia Icaro CornagliaDepartment of Public Health, Experimental and Forensic Medicine, University of Pavia, via Forlanini 2, 27100 Pavia, Italy.
Silvia RossiDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Giuseppina SandriDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects and implant-associated infections remain major challenges in orthopedic reconstruction, requiring multifunctional biomaterials able to promote osteointegration while preventing bacterial colonization. This work aimed to develop an electrospun nanofibrous membrane based on thermoplastic polyurethane (TPU) and hydroxyapatite (HAp), coated with hyaluronic acid (HA) and functionalized with titanium dioxide (TiO₂) nanoparticles as lining of orthopedic implants. The developed membranes were characterized in terms of morphology, surface properties, mechanical performance, degradation, antibacterial activity, and biological response. The HA-TiO₂-coated membrane showed increased surface wettability and roughness compared with uncoated TPU-based membranes, while maintaining fibrous morphology. After 6 weeks in phosphate-buffered solution, uncoated membranes showed approximately 6% mass loss, whereas HA-coated membranes showed approximately 50% mass loss during the first week, consistent with partial coating removal. The TiO₂-containing membrane reduced bacterial viability after 24 h, corresponding to approximately 1.31 and 1.05 log₁₀ reductions for

Indexed as

Bone tissue engineeringHyaluronic acidHydroxyapatiteOsteoconductivitySurgical site infection preventionThermoplastic polyurethaneTitanium dioxide nanoparticles

Identifiers

PMID42751347
PMCPMC13579446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.