Evidence map›Paper›PMID 42751327›Full record

ArticleOpen forum infectious diseases2026

Plasma Microbial Cell-Free DNA Sequencing for the Diagnosis of Chronic Disseminated Candidiasis in Patients with Hematologic Malignancies.

Alejandro De La Hoz, Victor Kovac, Ann E Woolley, Nicolas C Issa, Alyssa Letourneau, Lindsey R Baden, Sarah P Hammond, Jessica S Little

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alejandro De La HozDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9073-1258
Victor KovacDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-1811-6565
Ann E WoolleyDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Nicolas C IssaDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Alyssa LetourneauDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
Lindsey R BadenDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Sarah P HammondDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-4271-7443
Jessica S LittleDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-8093-5647

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnosis of chronic disseminated candidiasis (CDC) is frequently delayed because clinical manifestations are nonspecific and conventional diagnostic tests have limited sensitivity. We describe a series of 19 CDC cases in which plasma microbial cell-free DNA sequencing was performed due to diagnostic uncertainty. Results influenced antifungal management in most cases.

Indexed as

candidiasiscell-free nucleic acidsinvasive fungal infectionsleukemiametagenomics

Identifiers

PMID42751327
PMCPMC13579477

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.