ArticleJournal of oral microbiology2026
Anaerobic stress index to predict microbial ecological shifts in clear aligners.
Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Objectives: Clear aligners are clinically perceived as periodontally 'friendlier' than fixed appliances (FA), yet localized gingivitis persists. Salivary diagnostics often mask site-specific dysbiosis through a 'dilution effect'. This study aimed to characterize distinct ecological pressures and propose a novel anaerobic stress index (ASI) to quantify localized microbial burden. Methods: A computational meta-analysis was conducted using longitudinal 16S rRNA sequencing datasets ( Results: Saliva acts as a 'dilution filter,' failing to capture sessile biofilm dynamics (AUC = 0.51 in FA). Fixed appliances exhibited mechanical dysbiosis with a 2.64-fold increase in Conclusions: Physical entrapment in fixed appliances versus micro-environmental hypoxia under clear aligners drives divergent dysbiotic pathways. The ASI serves as a robust biomarker for subclinical dysbiosis, suggesting periodic re-oxygenation therapeutics are necessary to restore host-microbe homeostasis.
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