ArticleOpen forum infectious diseases2026
High-Throughput Characterization of Human Fibroblast Responses to a Panel of
Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Background: Method: Fifty-two recombinant Results: Unsupervised analysis identified 3 distinct host-response clusters, with concordant separation observed across hierarchical clustering (Ward.D2) and t-distributed stochastic neighbor embedding (t-SNE) projection. These clusters can be broadly defined as a cytotoxic/inflammatory antigen cluster (Cluster_1), enriched for key virulence factors (eg, HlgA, Atl.1, SasG.2) and characterized by marked upregulation of inflammatory mediators (including IL-6, IL-8, CXCL1, and CCL3). An immune modulation/surface protein cluster (Cluster_2), comprising adhesins and immune-evasion proteins (eg, Chp, SSL11, Atl.2), was associated with selective upregulation of AXIN1, IL-33, and DECR1. A small outlier antigen cluster (Cluster_4), consisting of LuKE and SdrD.1, did not exhibit a clearly defined host-response profile. Differential expression analysis identified 12 core host proteins-including COL1A1, CXCL1, CXCL16, DLK-1, GLO1, IGFBP-1, IL33, IL6, IL8, MCP-1, TNF, and TRAIL-R2-with consistent and significant changes across clusters (false discovery rate [FDR]-adjusted Conclusions: This preliminary study suggests that
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