ArticleAnnals of the Child Neurology Society2026
Exploring Healthcare Continuity in Pediatric-Onset Multiple Sclerosis in the United States.
Article in Annals of the Child Neurology Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
32 authors.
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Abstract
Objective: Little is known about shifting from pediatric to adult-focused multiple sclerosis (MS) care. This study aims to explore transition of care and follow-up in the US pediatric-onset MS (POMS) population. Methods: Surveys were distributed to 10 sites in the US Network of Pediatric MS Centers (US NPMSC) about transition-of-care practices. A cohort of POMS/clinically isolated syndrome (CIS) at 12 US NPMSC sites was analyzed. The primary comparison was between < 18 and ≥ 18-years of age. The primary outcome was 1- and 2-year lapse in last follow-up visit, measured from last recorded database visit to data lock date or, if ≥ 18 years of age, up to 1 year after a patient reached their site's typical transition age, if earlier. Secondary outcomes were baseline factors associated with follow-up lapse. The model was adjusted for preidentified confounders. Results: Compared with < 18 years, age ≥ 18 was associated with greater hazard of 1- and 2-year follow-up lapse. In POMS/CIS, the estimated hazard was 1.61 for 1-year lapse (95% confidence interval [CI] 1.32-1.97, Conclusion: Variable transition-of-care practices and barriers were reported by major US POMS centers. Before typical transition age, age ≥ 18 was associated with greater hazard of 1- and 2-year follow-up lapse than < 18. Developing standardized, targeted transition-of-care practices in POMS may be important.
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