ArticleCureus2026
Rocky Mountain Spotted Fever Presenting as an Ischemic Stroke: A Rare Manifestation.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rocky Mountain spotted fever (RMSF) is among the most severe tick-borne rickettsial infections encountered in the United States. Its presentation ranges from the classic triad of fever, headache, and rash to central nervous system (CNS) conditions, including meningitis, encephalitis, and seizures. Notably, RMSF presenting as an ischemic stroke due to CNS vasculitis is rare, which can prove fatal if recognition is delayed.We present the case of a woman in her 50s with a history of well-controlled diabetes mellitus type 2 and hypertension, who presented with fever, chills, body aches, and rash. She developed a headache and confusion. Routine laboratory tests showed thrombocytopenia, hyponatremia, and transaminitis. Brain magnetic resonance imaging (MRI) with and without gadolinium demonstrated scattered punctate foci of restricted diffusion throughout both cerebral hemispheres, consistent with acute lacunar infarcts involving multiple vascular territories, raising concern for vasculitis. Initial RMSF immunoglobulin G (IgG) was negative, but repeat testing showed a greater than fourfold elevation of IgG level, along with a positive plasma microbial cell-free DNA assay (Karius Inc., Redwood City, California, United States) for
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