Evidence map›Paper›PMID 42751046›Full record

ArticleOpen forum infectious diseases2026

A Retrospective Analysis Examining the Impact of Educational Attainment and Social Determinants of Health on Rifampicin-Resistant Tuberculosis Treatment Outcomes.

Titilade Kehinde Ayandeyi Teibo, Rubeshan Perumal, Lateef Babatunde Amusa, Letitia Shunmugam, Nonkululeko Mzinyane, Darshan Chetty, Resha Boodhram, Radhamoney Narasimmulu, Takondwa Kachoka, Claudia Shozi and 7 more

Abstract read
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In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Titilade Kehinde Ayandeyi TeiboDepartment of Maternal and Child Nursing and Public Health, University of São Paulo, College of Nursing at Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil.
Rubeshan PerumalCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.ORCID https://orcid.org/0000-0001-8892-2904
Lateef Babatunde AmusaCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Letitia ShunmugamCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Nonkululeko MzinyaneCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Darshan ChettyCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Resha BoodhramCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Radhamoney NarasimmuluCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Takondwa KachokaClinical HIV Research Unit (CHRU), Jose Pearson TB Hospital, Wits Health Consortium Pty Ltd, Port Elizabeth, South Africa.
Claudia ShoziCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Max R O'DonnellCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Allison WolfDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, New York, USA.
Sunitha ChotooDrug-resistant Tuberculosis Unit, King Dinuzulu Hospital Complex, Sydenham, Durban, South Africa.
Nalini SinghDrug-resistant Tuberculosis Unit, King Dinuzulu Hospital Complex, Sydenham, Durban, South Africa.
Ricardo Alexandre ArcêncioDepartment of Maternal and Child Nursing and Public Health, University of São Paulo, College of Nursing at Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil.
Nesri PadayatchiCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Kogieleum NaidooCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.ORCID https://orcid.org/0000-0002-8874-6661

Funding

Promoting Engagement in the Drug Resistant TB/HIV Care Continuum in South AfricaR01AI124413 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI O'DONNELL, MAX, PADAYATCHI, NESRI · 2016 to 2020
$2.7M
NIAID NIH HHS R01 AI124413
6 · The paper itself

Abstract

Background: Rifampicin-resistant tuberculosis (RR-TB) remains a major public health challenge in TB-endemic regions. While social determinants of health affect infectious disease outcomes, their impact on RR-TB remains poorly understood. This study evaluated the relationship between educational attainment, social disadvantage, and RR-TB outcomes. Method: We conducted a retrospective cohort study using data from 4 Centre for the AIDS Programme of Research in South Africa RR-TB clinical trials. Social vulnerability was measured using an exploratory Social Disadvantage Score (SDS) that incorporated education, employment, and incarceration. We used a latent class analysis (LCA) to identify classes with shared social vulnerability indicators. Associations with treatment outcomes were assessed using Cox regression models, with the exploratory SDS, its component indicators, and derived latent classes as predictors. Results: Education was not independently associated with unfavorable treatment outcomes (adjusted hazard ratio [aHR] = 1.39, 95% confidence interval [CI]: 0.96-1.99, Conclusions: Cumulative social risk score was associated with unfavorable RR-TB outcomes, supporting further evaluation of targeted support for disadvantaged populations.

Indexed as

educational attainmentrifampicin-resistant tuberculosissocioeconomic statusSouth Africatreatment outcomes

Identifiers

PMID42751046
PMCPMC13579474

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.