ArticleJCEM case reports2026
Osteoblastic skeletal metastases mimicking high-bone-turnover metabolic bone disease in gastric adenocarcinoma.
Article in JCEM case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Markedly elevated bone-specific alkaline phosphatase with radiographic skeletal abnormalities is a common endocrine presentation, most often attributed to disorders with high bone turnover, including Paget disease of bone or osteomalacia. Rarely, tumor-driven osteoblastic metastases may closely mimic this biochemical and radiographic phenotype, thereby potentially delaying the diagnosis of occult malignancy. This report describes a 50-year-old woman presenting with progressive dyspnea and constitutional symptoms who was found to have massive pericardial effusion with cardiac tamponade requiring pericardiocentesis. Imaging revealed diffuse osteosclerotic lesions with axial skeleton involvement. Laboratory examination showed markedly elevated alkaline phosphatase with a disproportionately high bone-specific component, alongside mild hypocalcemia, secondary hyperparathyroidism, and severe vitamin D deficiency, initially suggesting a high-bone-turnover metabolic bone disorder. However, whole-body fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (
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